Rabbit SLITRK5 Polyclonal Antibody | anti-SLITRK5 antibody

SLITRK5, CT (CXorf2, DKFZp451E1911, KIAA1854, MGC129912, MGC129913, SLIT and NTRK-like protein 2 precursor, SLITL1, UNQ9197/PRO34756)

Cat. Num. AAA621066

• Gene Names: SLITRK5; LRRC11; FLJ58374; KIAA0918; bA364G4.2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: SLITRK5; Polyclonal Antibody; CT (CXorf2; DKFZp451E1911; KIAA1854; MGC129912; MGC129913; SLIT and NTRK-like protein 2 precursor; SLITL1; UNQ9197/PRO34756); Anti -SLITRK5; anti-SLITRK5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Slitrk2. Species crossreactivity: Mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-SLITRK5 antibody: Western Blot (WB)
• Application Notes: Dilution: Western Blot: 1-2 ug/ml.; Rat brain tissue lysate can be used as positive control.
• Immunogen: Synthetic peptide corresponding to 17aa from near the carboxy terminus of human Slitrk2 (GenBank accession no. Q9H156).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot analysis of Slitrk2 in rat brain tissue lysate with Slitrk2 antibody at (A) 1 and (B) 2 ug/ml.)

Related Product Information for anti-SLITRK5 antibody

SLIT and NTRK-like family 2 (Slitrk2) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains (1). Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk2 is expressed primarily in neurons in the ventricular layer of the brain (1,2). Like every other Slitrk protein except Slitrk1, overexpression of Slitrk2 inhibited neurite outgrowth in cultured neurons. Deletion analysis indicated that the functional difference between Slitrk2 and Slitrk1 is within their intracellular domains (1). At least two isoforms of this protein are known to exist. This antibody is predicted to have no cross-reactivity to other Slitrk proteins.

Product Categories/Family for anti-SLITRK5 antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 40217823
• NCBI GeneID: 26050
• NCBI Accession #: NP_056382.1
• NCBI GenBank Nucleotide #: NM_015567.1
• UniProt Accession #: O94991; Q5VT81; B3KNB8; Q4QQH1
• Molecular Weight: 107,486 Da
• NCBI Official Full Name: SLIT and NTRK-like protein 5
• NCBI Official Synonym Full Names: SLIT and NTRK-like family, member 5
• NCBI Official Symbol: SLITRK5
• NCBI Official Synonym Symbols: LRRC11; FLJ58374; KIAA0918; bA364G4.2
• NCBI Protein Information: SLIT and NTRK-like protein 5; OTTHUMP00000018547; slit and trk like gene 5; leucine rich repeat containing 11; leucine-rich repeat-containing protein 11
• UniProt Protein Name: SLIT and NTRK-like protein 5
• Protein Family: SLIT and NTRK-like protein
• UniProt Gene Name: SLITRK5
• UniProt Synonym Gene Names: KIAA0918; LRRC11
• UniProt Entry Name: SLIK5_HUMAN

NCBI Description

Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM]

Uniprot Description

SLITRK5: Suppresses neurite outgrowth. Belongs to the SLITRK family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q31.2

Cellular Component: integral to membrane; receptor complex

Biological Process: grooming behavior; skin development; response to xenobiotic stimulus; synaptic transmission; striatum development; axonogenesis; dendrite morphogenesis; adult behavior