Rabbit Slitrk2 Polyclonal Antibody | anti-SLITRK2 antibody

Slitrk2 Antibody

Cat. Num. AAA150535

• Gene Names: SLITRK2; CXorf2; SLITL1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Slitrk2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: Slitrk2; Polyclonal Antibody; Slitrk2 Antibody; CXorf2; SLITL1; KIAA1854; UNQ9197/PRO34756; SLIT and NTRK-like protein 2; SLIT and NTRK-like family; member 2; anti-SLITRK2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This antibody is predicted to have no cross-reactivity to other Slitrk proteins.
• Purity/Purification: Slitrk2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 845

• Applicable Applications for anti-SLITRK2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Slitrk2 antibody can be used for detection of Slitrk2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: Slitrk2 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human Slitrk2.
• Buffer: Slitrk2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Slitrk2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of Slitrk2 in rat brain tissue lysate with Slitrk2 antibody at (A) 1 and (B) 2 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of Slitrk2 in human brain tissue with Slitrk2 antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of Slitrk2 in Human Brain cells with Slitrk2 antibody at 20 μg/mL.)

Related Product Information for anti-SLITRK2 antibody

Slitrk2 Antibody: SLIT and NTRK-like family 2 (Slitrk2) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk2 is expressed primarily in neurons in the ventricular layer of the brain. Like every other Slitrk protein except Slitrk1, overexpression of Slitrk2 inhibited neurite outgrowth in cultured neurons. Deletion analysis indicated that the functional difference between Slitrk2 and Slitrk1 is within their intracellular domains. At least two isoforms of this protein are known to exist.

NCBI and Uniprot Product Information

• NCBI GI #: 46397026
• NCBI GeneID: 84631
• UniProt Accession #: Q9H156; Q2KHN3; Q5JXB1; Q8NBC7; Q96JH3; A8K117
• Molecular Weight: 82,695 Da
• NCBI Official Full Name: SLIT and NTRK-like protein 2
• NCBI Official Synonym Full Names: SLIT and NTRK-like family, member 2
• NCBI Official Symbol: SLITRK2
• NCBI Official Synonym Symbols: CXorf2; SLITL1
• NCBI Protein Information: SLIT and NTRK-like protein 2; slit-like 1; slit and trk like gene 2
• UniProt Protein Name: SLIT and NTRK-like protein 2
• Protein Family: SLIT and NTRK-like protein
• UniProt Gene Name: SLITRK2
• UniProt Synonym Gene Names: CXorf2; KIAA1854; SLITL1
• UniProt Entry Name: SLIK2_HUMAN

NCBI Description

This gene encodes an integral membrane protein that contains two N-terminal leucine-rich repeats domains and contains C-terminal regions similar to neurotrophin receptors. The encoded protein may play a role in modulating neurite activity. Alternatively spliced transcript variants encoding the same protein have been described.[provided by RefSeq, Feb 2010]

Uniprot Description

SLITRK2: Suppresses neurite outgrowth. Belongs to the SLITRK family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq27.3

Cellular Component: integral to membrane

Biological Process: axonogenesis