Rabbit Slitrk6 Polyclonal Antibody | anti-SLITRK6 antibody

Slitrk6, CT (SLIT and NTRK-like family 6, FLJ22774, FLJ22774, MGC119595, MGC119596, MGC119597, SLIT and NTRK-like protein 6 precursor)

Cat. Num. AAA620322

• Gene Names: SLITRK6; MGC119595; MGC119596; MGC119597
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Slitrk6; Polyclonal Antibody; CT (SLIT and NTRK-like family 6; FLJ22774; MGC119595; MGC119596; MGC119597; SLIT and NTRK-like protein 6 precursor); Anti -Slitrk6; anti-SLITRK6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Slitrk6. Species crossreactivity: Mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-SLITRK6 antibody: Western Blot (WB)
• Application Notes: Dilution: Western Blot: 0.5-1ug/ml
• Immunogen: Synthetic peptide corresponding to 16aa from near the carboxy terminus of human Slitrk6 (GenBank accession no. Q9H5Y7).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot analysis of Slitrk6 in SK-N-SH cell lysate with Slitrk6 antibody at (A) 0.5 and (B) 1 ug/ml.)

Related Product Information for anti-SLITRK6 antibody

SLIT and NTRK-like family 6 (Slitrk6) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains (1). Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family (1,2). Slitrk6 expression has been observed in tissues such as tongue, lung, gastrointestinal tract, and pancreas (3). Like every other Slitrk protein except Slitrk1, overexpression of Slitrk6 inhibited neurite outgrowth in cultured neurons, suggesting that these proteins are involved in the control of neurite outgrowth.

Product Categories/Family for anti-SLITRK6 antibody

Antibodies; Abs to Membrane Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 40217825
• NCBI GeneID: 84189
• NCBI Accession #: NP_115605.2
• NCBI GenBank Nucleotide #: NM_032229.2
• UniProt Accession #: Q9H5Y7; Q495Q0; Q6AW93; Q9HAA8; Q9NT60; A8K9S8
• Molecular Weight: 95,110 Da
• NCBI Official Full Name: SLIT and NTRK-like protein 6
• NCBI Official Synonym Full Names: SLIT and NTRK-like family, member 6
• NCBI Official Symbol: SLITRK6
• NCBI Official Synonym Symbols: MGC119595; MGC119596; MGC119597
• NCBI Protein Information: SLIT and NTRK-like protein 6; 4832410J21Rik; OTTHUMP00000218559; slit and trk like gene 6
• UniProt Protein Name: SLIT and NTRK-like protein 6
• Protein Family: SLIT and NTRK-like protein
• UniProt Gene Name: SLITRK6
• UniProt Entry Name: SLIK6_HUMAN

NCBI Description

Members of the SLITRK family, such as SLITRK6, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK6, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM]

Uniprot Description

SLITRK6: Suppresses neurite outgrowth. Belongs to the SLITRK family.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q31.1

Cellular Component: cell surface; integral to plasma membrane

Biological Process: vestibulocochlear nerve development; lens development in camera-type eye; startle response; synaptogenesis; sensory perception of sound; visual perception; axonogenesis; adult locomotory behavior; multicellular organism growth; auditory receptor cell morphogenesis; auditory behavior; linear vestibuloocular reflex

Disease: Deafness And Myopia