Rabbit Slitrk5 Polyclonal Antibody | anti-SLITRK5 antibody

Slitrk5 Antibody

Cat. Num. AAA151545

• Gene Names: SLITRK5; LRRC11; bA364G4.2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Slitrk5 Antibody is affinity chromatography purified via peptide column.
• Synonyms: Slitrk5; Polyclonal Antibody; Slitrk5 Antibody; LRRC11; bA364G4.2; KIAA0918; SLIT and NTRK-like protein 5; Leucine-rich repeat-containing protein 11; SLIT and NTRK-like family; member 5; anti-SLITRK5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This antibody is predicted to have no cross-reactivity to other Slitrk proteins.
• Purity/Purification: Slitrk5 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 958

• Applicable Applications for anti-SLITRK5 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Slitrk5 antibody can be used for detection of Slitrk5 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: Slitrk5 antibody was raised against a 15 amino acid synthetic peptide from near the center of human Slitrk5.
• Buffer: Slitrk5 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Slitrk5 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of Slitrk5 in 3T3 cell lysate with Slitrk5 antibody at 1 μg/mL in the (A) absence or (B) presence of blocking peptide.)

Immunohistochemistry (IHC)

(Immunohistochemistry of Slitrk5 in human brain tissue with Slitrk5 antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of slitrk5 in human brain tissue with slitrk5 antibody at 20 μg/mL.)

Related Product Information for anti-SLITRK5 antibody

Slitrk5 Antibody: SLIT and NTRK-like family 5 (Slitrk5) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family. Like every other Slitrk protein except Slitrk1, overexpression of Slitrk5 inhibited neurite outgrowth in cultured neurons, suggesting that these proteins are involved in the control of neurite outgrowth.

NCBI and Uniprot Product Information

• NCBI GI #: 46397810
• NCBI GeneID: 26050
• UniProt Accession #: O94991; Q5VT81; B3KNB8; B4DSH5
• Molecular Weight: 79,766 Da
• NCBI Official Full Name: SLIT and NTRK-like protein 5
• NCBI Official Synonym Full Names: SLIT and NTRK-like family, member 5
• NCBI Official Symbol: SLITRK5
• NCBI Official Synonym Symbols: LRRC11; bA364G4.2
• NCBI Protein Information: SLIT and NTRK-like protein 5; slit and trk like gene 5; leucine rich repeat containing 11; leucine-rich repeat-containing protein 11
• UniProt Protein Name: SLIT and NTRK-like protein 5
• Protein Family: SLIT and NTRK-like protein
• UniProt Gene Name: SLITRK5
• UniProt Synonym Gene Names: KIAA0918; LRRC11
• UniProt Entry Name: SLIK5_HUMAN

NCBI Description

Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]

Uniprot Description

SLITRK5: Suppresses neurite outgrowth. Belongs to the SLITRK family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q31.2

Cellular Component: integral to membrane; receptor complex

Biological Process: grooming behavior; skin development; response to xenobiotic stimulus; synaptic transmission; striatum development; axonogenesis; adult behavior; dendrite morphogenesis