Rabbit Slitrk4 Polyclonal Antibody | anti-SLITRK4 antibody

Slitrk4, NT (SLIT and NTRK-like family 4, DKFZp547M2010, SLIT and NTRK-like protein 4 precursor)

Cat. Num. AAA620799

• Gene Names: SLITRK4; DKFZp547M2010
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Slitrk4; Polyclonal Antibody; NT (SLIT and NTRK-like family 4; DKFZp547M2010; SLIT and NTRK-like protein 4 precursor); Anti -Slitrk4; anti-SLITRK4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Slitrk4. Species crossreactivity: Mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-SLITRK4 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 0.5-1ug/ml
• Immunogen: Synthetic peptide corresponding to 14aa from near the amino terminus of human Slitrk4 (GenBank accession no. Q8IW52).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot analysis of Slitrk4 in mouse brain tissue lysate with Slitrk4 antibody at (A) 0.5 and (B) 1 ug/ml.)

Related Product Information for anti-SLITRK4 antibody

SLIT and NTRK-like family 4 (Slitrk4) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains (1). Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family (1,2). Like every other Slitrk protein except Slitrk1, overexpression of Slitrk4 inhibited neurite outgrowth in cultured neurons, suggesting that these proteins are involved in the control of neurite outgrowth. This antibody is predicted to have no cross-reactivity to other Slitrk proteins.

Product Categories/Family for anti-SLITRK4 antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 296080775
• NCBI GeneID: 139065
• NCBI Accession #: NP_001171679.1
• NCBI GenBank Nucleotide #: NM_001184750.1
• UniProt Accession #: Q8IW52; Q5JXG3; Q8TCM8; Q96DL3
• Molecular Weight: 94,331 Da
• NCBI Official Full Name: SLIT and NTRK-like protein 4
• NCBI Official Synonym Full Names: SLIT and NTRK-like family, member 4
• NCBI Official Symbol: SLITRK4
• NCBI Official Synonym Symbols: DKFZp547M2010
• NCBI Protein Information: SLIT and NTRK-like protein 4; OTTHUMP00000024187; OTTHUMP00000024188; slit and trk like gene 4
• UniProt Protein Name: SLIT and NTRK-like protein 4
• Protein Family: SLIT and NTRK-like protein
• UniProt Gene Name: SLITRK4
• UniProt Entry Name: SLIK4_HUMAN

NCBI Description

This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Uniprot Description

SLITRK4: Suppresses neurite outgrowth. Belongs to the SLITRK family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq27.3

Cellular Component: integral to membrane

Biological Process: axonogenesis