Western Blot (WB)
(Sample Data: Representative Western blot with Anti-SH2D1A (SAP) (1:1000) using 15 ug, 30 ug and 60 ug of Jurkat cell lysate.)
Rabbit SH2D1A (SAP) Polyclonal Antibody | anti-SH2D1A antibody
Anti-SH2D1A (SAP)
Reactivity
Western blot human SH2D1A (SAP)SH2D1A (SAP) from other species may also be detectable.
Applications
Western Blot
Purity
Affinity chromatography
Synonyms
SH2D1A (SAP); Polyclonal Antibody; Anti-SH2D1A (SAP); anti-SH2D1A antibody
Host
Rabbit
Reactivity
Western blot human SH2D1A (SAP)
SH2D1A (SAP) from other species may also be detectable.
SH2D1A (SAP) from other species may also be detectable.
Clonality
Polyclonal
Isotype
Rabbit
Specificity
Recognizes the SH2D1A (SAP) protein
Purity/Purification
Affinity chromatography
Form/Format
TBS, 50% glycerol
Applicable Applications for anti-SH2D1A antibody
Western Blot (WB)
Application Notes
WB: 18625:19624
Immunogen
Synthetic peptide corresponding to amino acids 113-128 of human SH2D1A (SAP)
Preparation and Storage
Store at 4 degree C (add 0.1% NaN3) for several months, and at -20 degree C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles.
Western Blot (WB)
(Sample Data: Representative Western blot with Anti-SH2D1A (SAP) (1:1000) using 15 ug, 30 ug and 60 ug of Jurkat cell lysate.)
Western Blot (WB)
(Sample Data: Representative Western blot with Anti-SH2D1A (SAP) (1:1000) using 15 ug, 30 ug and 60 ug of Jurkat cell lysate.)
Related Product Information for anti-SH2D1A antibody
SH2D1A contains an SH2 domain and a short tail, and expresses at a high level in thymus and lung. It acts as an inhibitor of the SLAM (signaling lymphocyte-activation molecule) proteins by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. It modifies signal transduction pathways in activated T, B and NK cells. SH2D1A mediates interaction between FYN and SLAMF1 (1). Mutations in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1)(2).
Product Categories/Family for anti-SH2D1A antibody
References
1. Chan B., et al: SAP couples Fyn to SLAM immune receptors. Nat. Cell Biol. 5:155-160(2003)
2. Dutz, J. P., et al: Lymphocytic vasculitis in X-linked lymphoproliferative disease. Blood 97: 95-100, 2001.
2. Dutz, J. P., et al: Lymphocytic vasculitis in X-linked lymphoproliferative disease. Blood 97: 95-100, 2001.
Similar Products
Product Notes
The SH2D1A (Catalog #AAA516204) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SH2D1A (SAP) reacts with Western blot human SH2D1A (SAP) SH2D1A (SAP) from other species may also be detectable. and may cross-react with other species as described in the data sheet. AAA Biotech's SH2D1A (SAP) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 18625:19624. Researchers should empirically determine the suitability of the SH2D1A for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SH2D1A (SAP), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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