Rabbit RHBDD3 Polyclonal Antibody | anti-RHBDD3 antibody

RHBDD3 Antibody

Cat. Num. AAA150595

• Gene Names: RHBDD3; PTAG; C22orf3; HS984G1A
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunofluorescence
• Purity: RHBDD3 Antibody is affinity chromatography purified via peptide column.
• Synonyms: RHBDD3; Polyclonal Antibody; RHBDD3 Antibody; PTAG; C22orf3; HS984G1A; Rhomboid domain-containing protein 3; rhomboid domain containing 3; anti-RHBDD3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: RHBDD3 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 386

• Applicable Applications for anti-RHBDD3 antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
• Application Notes: RHBDD3 antibody can be used for detection of RHBDD3 by Western blot at 1 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: RHBDD3 antibody was raised against a 13 amino acid synthetic peptide from near the center of human RHBDD3.
• Buffer: RHBDD3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: RHBDD3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of RHBDD3 in rat lung tissue lysate with RHBDD3 antibody at 1 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of RHBDD32 in rat lung tissue with RHBDD3 antibody at 20 μg/mL.)

Related Product Information for anti-RHBDD3 antibody

RHBDD3 Antibody: The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD3 was initially identified as a novel pituitary tumor apoptosis gene (PTAG) whose expression was reduced in certain pituitary adenomas. Overexpression of RHBDD3 in AtT20 cells showed an increase in apoptotic activity and caspase activation in response to bromocriptine, and apoptosis-inducing dopamine D2 analog, suggesting that reactivation of RHBDD3 in tumors may be a therapeutically useful tool. Later experiments also showed that RHBDD3 expression is also reduced in several primary colorectal tumors, indicating that loss of RHBDD3 contributes to a blunted apoptotic response and probably predisposes cells towards malignant transformation.

NCBI and Uniprot Product Information

• NCBI GI #: 11072101
• NCBI GeneID: 25807
• NCBI Accession #: NP_036397
• NCBI GenBank Nucleotide #: NM_012265.1
• UniProt Accession #: Q9Y3P4; Q6I9X3; Q9UGQ7
• Molecular Weight: 40,484 Da
• NCBI Official Full Name: rhomboid domain-containing protein 3
• NCBI Official Synonym Full Names: rhomboid domain containing 3
• NCBI Official Symbol: RHBDD3
• NCBI Official Synonym Symbols: PTAG; C22orf3; HS984G1A
• NCBI Protein Information: rhomboid domain-containing protein 3; pituitary tumor apoptosis
• UniProt Protein Name: Rhomboid domain-containing protein 3
• Protein Family: Rhomboid domain-containing protein
• UniProt Gene Name: RHBDD3
• UniProt Synonym Gene Names: C22orf3
• UniProt Entry Name: RHBD3_HUMAN

Uniprot Description

RHBDD3:

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: integral to membrane

Molecular Function: serine-type endopeptidase activity

Biological Process: response to xenobiotic stimulus; regulation of protein secretion; regulation of acute inflammatory response; negative regulation of natural killer cell activation; positive regulation of protein catabolic process; MAPKKK cascade; proteolysis; liver development