Western Blot (WB)
(Western Blot using Human Recombinant RANK Protein)
Rabbit RANK Polyclonal Antibody | anti-RANK antibody
RANK Antibody
Gene Names
TNFRSF11A; FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1
Applications
Western Blot, Immunohistochemistry
Purity
Affinity Chromatography
Synonyms
RANK; Polyclonal Antibody; RANK Antibody; Affinity Purified Rat Polyclonal RANK Antibody; Polyclonal RANK antibody; Anti-RANK antibody; Tnfrsf11a antibody; Receptor Activator of NF-kB antibody; Rank antibody; anti-RANK antibody
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Chromatography
Form/Format
Lyophilized Form
Sequence Length
616
Applicable Applications for anti-RANK antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Immunogen
RANK antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the N-terminal of human RANK as the immunogen
Preparation and Storage
Store at 4 degree C for short term storage. For long term storage aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.
Western Blot (WB)
(Western Blot using Human Recombinant RANK Protein)
Western Blot (WB)
(Western Blot using Human Recombinant RANK Protein)
Related Product Information for anti-RANK antibody
The R12-31 monoclonal antibody reacts with mouse RANK, a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-kappaB and c-Jun-terminal kinase pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-kappaB, whereas JNK activation is mediated through binding of RANK to TRAF2.
Product Categories/Family for anti-RANK antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
receptor activator of nuclear factor-kappa B
NCBI Official Synonym Full Names
TNF receptor superfamily member 11a
NCBI Official Symbol
TNFRSF11A
NCBI Official Synonym Symbols
FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1
NCBI Protein Information
tumor necrosis factor receptor superfamily member 11A
NCBI Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]
Research Articles on RANK
Similar Products
Product Notes
The RANK (Catalog #AAA5312710) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's RANK can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the RANK for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RANK, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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