Immunohistochemistry (IHC)-Paraffin
(The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using MBS7126785(RAB25 Antibody) at dilution 1/50. (Original magnification: 200))
Rabbit anti-Human, Mouse RAB25 Polyclonal Antibody | anti-RAB25 antibody
RAB25 Antibody
IHC: 1:50-1:150
Immunohistochemistry (IHC)-Paraffin
(The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using MBS7126785(RAB25 Antibody) at dilution 1/50. (Original magnification: 200))
Immunohistochemistry (IHC)-Paraffin
(The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using MBS7126785(RAB25 Antibody) at dilution 1/50. (Original magnification: 200))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015]
Uniprot Description
Function: Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Increases the rates of ovarian and breast cancers progression and aggressiveness by modulating cellular processes such as proliferation, survival and migration of epithelial tumor cells. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis
By similarity. Ref.7 Ref.8
Subunit structure: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent. Interacts with ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer. Ref.6 Ref.8
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side
Potential. Cell projection › pseudopodium membrane. Cytoplasmic vesicle. Note: Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips.
Tissue specificity: Expressed in ovarian epithelium (NOE) and breast tissue. Expressed in ovarian cancer; expression is increased relative to NOE cells. Expression in ovarian cancer is stage dependent, with stage III and stage IV showing higher levels than early stage cancers. Expressed in breast cancer; expression is increased relative to normal breast tissue. Ref.7
Sequence similarities: Belongs to the small GTPase superfamily. Rab family.
Sequence caution: The sequence AAF98238.1 differs from that shown. Reason: Frameshift at position 196. The sequence AAM69362.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
Research Articles on RAB25
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Product Notes
The RAB25 rab25 (Catalog #AAA7126785) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RAB25 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's RAB25 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). ELISA: 1:1000-1:5000 IHC: 1:50-1:150. Researchers should empirically determine the suitability of the RAB25 rab25 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RAB25, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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