Testing Data
Pazopanib, Inhibitor
Pazopanib
Purity
0.98
Synonyms
Pazopanib; inhibitor
Purity/Purification
0.98
Solubility
DMSO >=95mg/mL - Water >=95mg/mL - Ethanol >=2mg/mL
Formula
C21H23N7O2S.HCl
CAS Number
635702-64-6
Preparation and Storage
Store at-20 degree C 2 years.
Testing Data
Testing Data
Related Product Information for Pazopanib, inhibitor
VEGFR enzyme assays for VEGGR1, VEGFR2, and VEGFR3 were running in homogeneous time-resolved fluorescence (HTRF) format in 384-well microtiter plates using a purified, baculovirus-expressed glutathione-S-transferase (GST) fusion protein encoding the catalytic c-terminus of human VEGFR receptor kinases 1, 2, or 3. Pazopanib HCl showed good potency against all the human VEGFR receptors with an IC50 of 10, 30, and 47 nM for VEGFR-1,-2, and-3, respectively. Significant activity was also seen against the closely related tyrosine receptor kinases PDGFR beta, c-Kit, FGF-R1, and c-fms with IC50's of 84, 74, 140, and 146 nM, respectively. In cellular assays, in addition to inhibiting the VEGF-induced proliferation of HUVECs, Pazopanib HCl potently inhibited VEGF-induced phosphorylation of VEGFR-2 in HUVEC cells with an IC50 of ?8 nM. The cytochrome P450 profile was also improved with inhibition >10 muM against the isozymes tested, with the exception of 2C9 (7.9 muM). [1]
Product Categories/Family for Pazopanib, inhibitor
References
Harris PA, et al. J. Med. Chem. 2008; 51, 4632-4640 The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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Product Notes
The Pazopanib (Catalog #AAA8506392) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Pazopanib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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