Rabbit PTPN21 Polyclonal Antibody | anti-PTPN21 antibody

PTPN21 Polyclonal Antibody

Cat. Num. AAA3007040

• Gene Names: PTPN21; PTPD1; PTPRL10
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: PTPN21; Polyclonal Antibody; PTPN21 Polyclonal Antibody; Tyrosine-protein phosphatase non-receptor type 21; Protein-tyrosine phosphatase D1; PTPD1; anti-PTPN21 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: PTPN21 polyclonal antibody detects endogenous levels of PTPN21 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 1174

• Applicable Applications for anti-PTPN21 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human PTPN21.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of PTPN21 polyclonal antibody at 1:500 dilutionLane1:A549 whole cell lysateLane2:Raw264. 7 whole cell lysate Lane3:PC12 whole cell lysate)

Related Product Information for anti-PTPN21 antibody

The protein tyrosine phosphatase (PTP) family of proteins are signaling molecules that regulate processes such as cell growth, cell differentiation, oncogenic transformation and the mitotic cycle. PTPN21 (protein tyrosine phosphatase, non-receptor type 21), also known as PTPD1 or PTPRL10, is a 1, 174 amino acid member of the PTP family and localizes to both the cytoplasm and the cytoskeleton. Containing one FERM domain and one tyrosine-protein phosphatase domain, PTPN21 functions to catalyze the water-dependent conversion of a protein tyrosine phosphate into a protein tyrosine and a free phosphate and, via this catalytic activity, may be involved in liver regeneration and spermatogenesis. The gene encoding PTPN21 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome.

NCBI and Uniprot Product Information

• NCBI GI #: 290457654
• NCBI GeneID: 11099
• UniProt Accession #: Q16825
• Molecular Weight: ~ 133kDa
• NCBI Official Full Name: Tyrosine-protein phosphatase non-receptor type 21
• NCBI Official Synonym Full Names: protein tyrosine phosphatase non-receptor type 21
• NCBI Official Symbol: PTPN21
• NCBI Official Synonym Symbols: PTPD1; PTPRL10
• NCBI Protein Information: tyrosine-protein phosphatase non-receptor type 21
• UniProt Protein Name: Tyrosine-protein phosphatase non-receptor type 21
• Protein Family: Tyrosine-protein phosphatase non-receptor
• UniProt Gene Name: PTPN21
• UniProt Synonym Gene Names: PTPD1
• UniProt Entry Name: PTN21_HUMAN

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]