Rabbit anti-Human PTPD1 Polyclonal Antibody | anti-PTPN21 antibody

PTPD1, ID (Tyrosine-protein Phosphatase Non-receptor Type 21, Protein-tyrosine Phosphatase D1, PTPN21)

Cat. Num. AAA630244

• Gene Names: PTPN21; PTPD1; PTPRL10
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: PTPD1; Polyclonal Antibody; ID (Tyrosine-protein Phosphatase Non-receptor Type 21; Protein-tyrosine Phosphatase D1; PTPN21); Anti -PTPD1; anti-PTPN21 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PTPD1.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-PTPN21 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot, and Immunohistochemistry.; Dilution: ELISA: 1:1,000; Western Blot: 1:100-1:500; Immunohistochemistry: 1:10-1:50
• Immunogen: Synthetic peptide selected from the center region of human PTPD1 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in placenta tissue lysate (35ug/lane) using MBS630244. PTPD1(arrow) was detected using MBS630244.)

Western Blot (WB)

(Western Blot analysis in Jurkat whole cell lysate (20ug) using MBS630244 (1:1000). Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10,000. Predicted band size: 133kD. Blocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-PTPN21 antibody

PTPD1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.

Product Categories/Family for anti-PTPN21 antibody

Antibodies; Abs to Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 530403001
• NCBI GeneID: 11099
• NCBI Accession #: XP_005267344.1
• NCBI GenBank Nucleotide #: XM_005267287.1
• UniProt Accession #: Q16825
• Molecular Weight: 133,281 Da
• NCBI Official Full Name: tyrosine-protein phosphatase non-receptor type 21 isoform X1
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, non-receptor type 21
• NCBI Official Symbol: PTPN21
• NCBI Official Synonym Symbols: PTPD1; PTPRL10
• NCBI Protein Information: tyrosine-protein phosphatase non-receptor type 21; protein tyrosine phosphatase D1; protein-tyrosine phosphatase D1; dJ1175B15.2 (protein tyrosine phosphatase, non-receptor type 21)
• UniProt Protein Name: Tyrosine-protein phosphatase non-receptor type 21
• Protein Family: Tyrosine-protein phosphatase non-receptor
• UniProt Gene Name: PTPN21
• UniProt Synonym Gene Names: PTPD1
• UniProt Entry Name: PTN21_HUMAN

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]

Uniprot Description

PTPN21: is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]

Protein type: EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q31.3

Cellular Component: cytoskeleton; cytoplasm

Molecular Function: protein binding; protein tyrosine phosphatase activity

Biological Process: protein amino acid dephosphorylation