Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embeded human kidney using at dilution of 1:20.)
Rabbit anti-Human Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Polyclonal Antibody | anti-PTEN antibody
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Polyclonal Antibody
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embeded human kidney using at dilution of 1:20.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embeded human kidney using at dilution of 1:20.)
NCBI and Uniprot Product Information
Uniprot Description
PTEN: a phosphoinositide 3-phosphatase (PIP3) and a tumor suppressor implicated in a wide variety of human cancers. Dephosphorylates inositol phospholipids generated by the activation of the phosphoinositide 3 kinase (PI3K). A major negative regulator of the PI3K/Akt signaling pathway. Possesses a C-terminal regulatory domain that contains three phosphorylation sites which may regulate its stability.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Phosphatase, lipid; Tumor suppressor
Chromosomal Location of Human Ortholog: 10q23.3
Cellular Component: apical plasma membrane; cell projection; cytoplasm; cytosol; internal side of plasma membrane; neuron projection; nucleoplasm; nucleus; plasma membrane
Molecular Function: enzyme binding; identical protein binding; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; PDZ domain binding; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity
Biological Process: apoptosis; brain morphogenesis; cell migration; cell proliferation; central nervous system development; central nervous system neuron axonogenesis; dentate gyrus development; forebrain morphogenesis; G1/S-specific negative regulation of cyclin-dependent protein kinase activity; heart development; inositol phosphate dephosphorylation; inositol phosphate metabolic process; learning and/or memory; locomotor rhythm; locomotory behavior; multicellular organismal response to stress; myelin maintenance in the central nervous system; negative regulation of axonogenesis; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of focal adhesion formation; negative regulation of organ growth; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of protein amino acid phosphorylation; negative regulation of protein kinase B signaling cascade; nerve-nerve synaptic transmission; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of transcription factor activity; prepulse inhibition; protein amino acid dephosphorylation; protein kinase B signaling cascade; protein stabilization; regulation of cellular component size; regulation of cyclin-dependent protein kinase activity; regulation of protein stability; rhythmic synaptic transmission; social behavior; synapse maturation; synaptogenesis; T cell receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin
Disease: Bannayan-riley-ruvalcaba Syndrome; Cowden Syndrome 1; Endometrial Cancer; Glioma Susceptibility 2; Macrocephaly/autism Syndrome; Melanoma, Cutaneous Malignant, Susceptibility To, 1; Meningioma, Familial, Susceptibility To; Prostate Cancer; Squamous Cell Carcinoma, Head And Neck; Thyroid Carcinoma, Follicular; Vacterl Association With Hydrocephalus
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Product Notes
The PTEN pten (Catalog #AAA9415867) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:20 - 1:200. Researchers should empirically determine the suitability of the PTEN pten for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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