Western Blot (WB)
(Anti-TNFRSF4 rabbit polyclonal antibody at 1:500 dilutionLane A: Rat liver tissue lysateLysates/proteins at 30 ug per laneSecondaryGoat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.Developed using the ECL technique. Performed under reducing conditions.Predicted band size:30 kDaObserved band size:30 kDa)
Rabbit anti-Rat OX40 Polyclonal Antibody | anti-TNFRSF4 antibody
Anti-OX40 Antibody, Rabbit Polyclonal
Gene Names
Tnfrsf4; Ox40; Txgp1
Reactivity
Rat
Applications
Western Blot
Purity
Protein A & Antigen Affinity
Synonyms
OX40; Polyclonal Antibody; Anti-OX40 Antibody; Rabbit Polyclonal; OX40/TNFRSF4/CD134 Antibody; Rabbit PAb; Antigen Affinity Purified; tumor necrosis factor receptor superfamily; member 4; anti-TNFRSF4 antibody
Host
Rabbit
Reactivity
Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Rat OX40/TNFRSF4/CD134
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-TNFRSF4 antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:1000
Immunogen
A synthetic peptide corresponding to the center region of the Rat OX40/TNFRSF4/CD134
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Rat OX40/TNFRSF4/CD134, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Western Blot (WB)
(Anti-TNFRSF4 rabbit polyclonal antibody at 1:500 dilutionLane A: Rat liver tissue lysateLysates/proteins at 30 ug per laneSecondaryGoat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.Developed using the ECL technique. Performed under reducing conditions.Predicted band size:30 kDaObserved band size:30 kDa)
Western Blot (WB)
(Anti-TNFRSF4 rabbit polyclonal antibody at 1:500 dilutionLane A: Rat liver tissue lysateLysates/proteins at 30 ug per laneSecondaryGoat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.Developed using the ECL technique. Performed under reducing conditions.Predicted band size:30 kDaObserved band size:30 kDa)
Related Product Information for anti-TNFRSF4 antibody
OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.
Product Categories/Family for anti-TNFRSF4 antibody
References
Compaan D.M., et al. (2006).The crystal structure of the costimulatory OX40-OX40L complex. Structure 14:1321-1330.Kawamata S., et al. (1998).Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2-and TRAF5-mediated NF-kappaB activation. J. Biol. Chem. 273:5808-5814. Byun M., (2013) Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J. Exp. Med. 210:1743-1759.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
29,895 Da
NCBI Official Full Name
Tumor necrosis factor receptor superfamily member 4
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 4
NCBI Official Symbol
Tnfrsf4
NCBI Official Synonym Symbols
Ox40; Txgp1
NCBI Protein Information
tumor necrosis factor receptor superfamily member 4; MRC OX40; OX40 antigen; OX40L receptor; tumor necrosis factor superfamily, member 4; Tax-transcriptionally activated glycoprotein 1; tumor necrosis factor (ligand) superfamily member 4
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 4
Protein Family
UniProt Gene Name
Tnfrsf4
UniProt Synonym Gene Names
Ox40; Txgp1l
UniProt Entry Name
TNR4_RAT
NCBI Description
membrane-bound receptor, binds adaptor proteins Traf2 and Traf5; member of the tumor necrosis factor (TNF)-receptor superfamily [RGD, Feb 2006]
Uniprot Description
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity ().
Research Articles on TNFRSF4
Similar Products
Product Notes
The TNFRSF4 tnfrsf4 (Catalog #AAA8103532) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-OX40 Antibody, Rabbit Polyclonal reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's OX40 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:1000. Researchers should empirically determine the suitability of the TNFRSF4 tnfrsf4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OX40, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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