Rabbit BAG2 Polyclonal Antibody | anti-BAG2 antibody

BAG2 antibody - C-terminal region

Cat. Num. AAA3206228

• Gene Names: BAG2; BAG-2; dJ417I1.2
• Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
• Applications: Immunohistochemistry, Western Blot
• Purity: Protein A purified
• Synonyms: BAG2; Polyclonal Antibody; BAG2 antibody - C-terminal region; anti-BAG2 antibody

• Host: Rabbit
• Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
• Clonality: Polyclonal
• Purity/Purification: Protein A purified
• Form/Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Sequence: Synthetic peptide located within the following region: VDQKFQSIVIGCALEDQKKIKRRLETLLRNIENSDKAIKLLEHSKGAGSK
• Sequence Length: 211

• Applicable Applications for anti-BAG2 antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human BAG2
• Preparation and Storage: For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Immunohistochemistry (IHC)

(Rabbit Anti-BAG2 AntibodyParaffin Embedded Tissue: Human KidneyCellular Data: Epithelial cells of renal tubuleAntibody Concentration: 4.0-8.0 ug/mlMagnification: 400X)

Western Blot (WB)

(Host: RabbitTarget Name: BAG2Sample Tissue: Human HepG2Antibody Dilution: 1.0ug/ml)

Western Blot (WB)

(Sample Type :Lane 1: 20ug untransfected human Saos2 cells Lane 2: 20ug siRUVBL transfected human Saos2 cells Primary Antibody Dilution :1:1000 Secondary Antibody:Anti-rabbit-HRP Secondary Antibody Dilution:1:3000 Color/Signal Descriptions:BAG2 Gene Name:Wenwei Hu, Xuetian Yue, Rutgers Cancer Institute of New Jersey. Submitted by:)

Western Blot (WB)

(WB Suggested Anti-BAG2 Antibody Titration: 1.25ug/mlPositive Control: Jurkat cell lysateBAG2 is supported by BioGPS gene expression data to be expressed in Jurkat)

Related Product Information for anti-BAG2 antibody

This is a rabbit polyclonal antibody against BAG2. It was validated on Western Blot and immunohistochemistry

Target Description: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

Product Categories/Family for anti-BAG2 antibody

Polyclonal; Drugs and Drug Metabolism; DNA/RNA/Protein Interactions; Tissue Specific & Cell Marker; Immunohistochemistry

NCBI and Uniprot Product Information

• NCBI GI #: 4757834
• NCBI GeneID: 9532
• NCBI Accession #: NP_004273
• NCBI GenBank Nucleotide #: NM_004282
• UniProt Accession #: O95816
• Molecular Weight: 23kDa
• NCBI Official Full Name: BAG family molecular chaperone regulator 2
• NCBI Official Synonym Full Names: BCL2 associated athanogene 2
• NCBI Official Symbol: BAG2
• NCBI Official Synonym Symbols: BAG-2; dJ417I1.2
• NCBI Protein Information: BAG family molecular chaperone regulator 2
• UniProt Protein Name: BAG family molecular chaperone regulator 2
• Protein Family: BAG family molecular chaperone regulator
• UniProt Gene Name: BAG2
• UniProt Synonym Gene Names: BAG-2
• UniProt Entry Name: BAG2_HUMAN

NCBI Description

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

Uniprot Description

BAG2: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 6p12.1-p11.2

Molecular Function: identical protein binding; protein binding; chaperone binding

Biological Process: protein folding; protein metabolic process