Mouse anti-Human OSBPL8 Polyclonal Antibody | anti-OSBPL8 antibody

OSBPL8 (Oxysterol-binding Protein-related Protein 8, ORP-8, OSBP-related Protein 8, DKFZp686A11164, MGC126578, MGC133203, KIAA1451, ORP8, OSBP10)

Cat. Num. AAA6000469

• Gene Names: OSBPL8; ORP8; MST120; OSBP10; MSTP120
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: OSBPL8; Polyclonal Antibody; OSBPL8 (Oxysterol-binding Protein-related Protein 8; ORP-8; OSBP-related Protein 8; DKFZp686A11164; MGC126578; MGC133203; KIAA1451; ORP8; OSBP10); Anti -OSBPL8 (Oxysterol-binding Protein-related Protein 8; anti-OSBPL8 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human OSBPL8.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MSQRQGKEAYPTPTKDLHQPSLSPASPHSQGFERGKEDISQNKDESSLSMSKSKSESKLYNGSEKDSSTSSKLTKKESLKVQKKNYREEKKRATKELLSTITDPSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQKNGQWVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSYLIIRATSESDGRCWMDALELALKCSSLLKRTMIREGKEHDLSVSSDSTHVTFYGLLRANNLHSGDNFQLNDSEIERQHFKDQDMYSDKSDKENDQEHDESDNEVMGKSEESDTDTSERQDDSYIEPEPVEPLKETTYTEQSHEELGEAGEASQTETVSEENKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVNQISGKLKLGKEVLATLEGHWDSEVFITDKKTDNSEVFWNPTPDIKQWRLIRHTVKFEEQGDFESEKLWQRVTRAINAKDQTEATQEKYVLEEAQRQAARDRKTKNEEWSCKLFELDPLTGEWHYKFADTRPWDPLNDMIQFEKDGVIQTKVKHRTPMVSVPKMKHKPTRQQKKVAKGYSSPEPDIQDSSGSEAQSVKPSTRRKKGIELGDIQSSIESIKQTQEEIKRNIMALRNHLVSSTPATDYFLQQKDYFIIFLLILLQVIINFMFK

• Applicable Applications for anti-OSBPL8 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human OSBPL8, aa1-847 (NP_001003712.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of OSBPL8 expression in transfected 293T cell line by OSBPL8 polyclonal antibody. Lane 1: OSBPL8 transfected lysate (93.17kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-OSBPL8 antibody

ORP8 is a member of the oxysterol-binding protein related protein family. In humans, the gene family consists of 12 members, and extensive splice variation increases the number of encoded protein products substantially. The ORPs have been implicated as sterol sensors that regulate a number of cellular functions including sterol and neutral lipid metabolism, intracellular lipid transport, membrane trafficking and cell signaling. ORP8 has been recently shown to act as a sterol sensor that affects the reverse cholesterol transport process via modulation of ABCA1 expression and macrophage cholesterol efflux.

Product Categories/Family for anti-OSBPL8 antibody

Antibodies; Abs to Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 51895890
• NCBI GeneID: 114882
• UniProt Accession #: Q9BZF1; Q52LQ3; Q68D75; Q8WXP8; Q9P277; A8K1T2; E9PE66; E9PE68
• Molecular Weight: 101,196 Da
• NCBI Official Full Name: OSBPL8 protein, partial
• NCBI Official Synonym Full Names: oxysterol binding protein-like 8
• NCBI Official Symbol: OSBPL8
• NCBI Official Synonym Symbols: ORP8; MST120; OSBP10; MSTP120
• NCBI Protein Information: oxysterol-binding protein-related protein 8; ORP-8; OSBP-related protein 8
• UniProt Protein Name: Oxysterol-binding protein-related protein 8
• Protein Family: Oxysterol-binding protein-related protein
• UniProt Gene Name: OSBPL8
• UniProt Synonym Gene Names: KIAA1451; ORP8; OSBP10; ORP-8
• UniProt Entry Name: OSBL8_HUMAN

NCBI Description

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

OSBPL8: a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two splice variant isoforms have been described.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 12q14

Cellular Component: nuclear membrane; membrane

Molecular Function: cholesterol binding

Biological Process: fat cell differentiation; positive regulation of protein kinase B signaling cascade; positive regulation of insulin receptor signaling pathway; lipid transport; negative regulation of cell migration