Rabbit Mupp1 Polyclonal Antibody | anti-MPDZ antibody

Mupp1 Antibody

Cat. Num. AAA9612439

• Gene Names: MPDZ; HYC2; MUPP1
• Reactivity: Human, Mouse, Rat; Predicted Reactivity: Rabbit(100%), Chicken(100%)
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: Mupp1; Polyclonal Antibody; Mupp1 Antibody; MPDZ; Multi PDZ domain protein 1; Multi-PDZ domain protein 1; multiple PDZ domain protein; anti-MPDZ antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat; Predicted Reactivity: Rabbit(100%), Chicken(100%)
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Mupp1 Antibody detects endogenous levels of total Mupp1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 2037

• Applicable Applications for anti-MPDZ antibody: ELISA (EIA)
• Application Notes: WB: 1:500-1:2000; ELISA(peptide): 1:20,000-1:40,000
• Immunogen: A synthesized peptide derived from human Mupp1, corresponding to a region within C-terminal amino acids.
• Fragment: Fab fragment
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of extracts from Hela cells, using Mupp1 Antibody. The lane on the left was treated with blocking peptide.)

Related Product Information for anti-MPDZ antibody

Function: Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.

Subcellular Location: Cell membrane>Peripheral membrane protein>Cytoplasmic side. Apical cell membrane>Peripheral membrane protein>Cytoplasmic side. Cell junction>Synapse>Postsynaptic density. Cell projection>Dendrite. Cell junction>Tight junction. Cell junction>Synapse. Cell junction>Synapse>Synaptosome. Note: Associated with membranes. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR.

Tissue Specificity: Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.

Subunit Structure: Interacts with CLDN5, DLG4, GRIN1, F11R/JAM, CLDN1, NG2, CRB1, MPP4 and MPP5 (By similarity). Interacts with HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1, PLEKHA2/TAPP2, CXADR, SYNGAP1, CAMK2A and CAMK2B. Interacts with FAT4 (via cytoplasmic domain) (By similarity). Interacts with DLL1 (By similarity).(Microbial infection) Interacts with human adenovirus type 9 E4-ORF1 protein.(Microbial infection) Interacts with human papillomavirus 18/HPV18 protein E6.

Similarity: The PDZ domain 1 binds NG2. The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT and the C-terminal PDZ-binding motif of HTR2C. The PDZ domain 13 binds CXADR (By similarity). The PDZ domain 2 binds CAMK2A and CAMK2B. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds SYNGAP1.

NCBI and Uniprot Product Information

• NCBI GI #: 387157892
• NCBI GeneID: 8777
• NCBI Accession #: NP_001248335.1
• NCBI GenBank Nucleotide #: NP_001248335.1
• UniProt Accession #: O75970
• Molecular Weight: Observed Molecular Weight: (Observed)221kD.; Predicted Molecular Weight: (Calculated)222kDa.
• NCBI Official Full Name: multiple PDZ domain protein isoform 2
• NCBI Official Synonym Full Names: multiple PDZ domain crumbs cell polarity complex component
• NCBI Official Symbol: MPDZ
• NCBI Official Synonym Symbols: HYC2; MUPP1
• NCBI Protein Information: multiple PDZ domain protein
• UniProt Protein Name: Multiple PDZ domain protein
• Protein Family: Multiple PDZ domain protein
• UniProt Gene Name: MPDZ
• UniProt Synonym Gene Names: MUPP1
• UniProt Entry Name: MPDZ_HUMAN

NCBI Description

The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]