Immunohistochemistry (IHC)
(Immunochemical staining of human KCNH7 in human rectum with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human KCNH7 Polyclonal Antibody | anti-KCNH7 antibody
Anti-KCNH7 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
KCNH7; Polyclonal Antibody; Anti-KCNH7 Antibody; Rabbit Polyclonal; KCNH7 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-ERG3 Antibody; Anti-Kv11.3 Antibody; anti-KCNH7 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human KCNH7
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-KCNH7 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:200-1:1000
Immunogen
E Coli-derived Human KCNH7 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human KCNH7 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human KCNH7 in human rectum with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human KCNH7 in human rectum with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human KCNH7 in cynomolgus heart with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human KCNH7 in cynomolgus heart with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-KCNH7 antibody
The Kv11 family, also called the HERG family, belongs to the subfamily H of the voltage-gated potassium (Kv) channels and plays an important role in the membrane potential regulation. The Kv11 family includes three members, which are KCNH2/Kv11.1, KCNH6/Kv11.2, and KCNH7/Kv11.3. All Kv11 channels are expressed in the nervous system. KCNH7 and KCNH2 are expressed in the brain, and KCNH6 is predominantly expressed in the superior mesenteric ganglia. These expression data indicate their functions in the nervous systemKCNH2 is a risk gene for schizophrenia. One study revealed that schizophrenia patients with different KCNH2 genotypes showed different responses to risperidone, a common antipsychotic drug used in the clinic. The Kv11 family plays an important role in the antipsychoticresponse.
References
Zouk H, et al. (2010) Study of transcriptional effects in cis at the ifih1 locus. PLoS One 5 (7): e11564.Wang X, et al. (2019) Association study of kcnh7 polymorphisms and individual responses to risperidone treatment in schizophrenia. Front Psychiatry 10 633.Strauss KA, et al. (2014) A population-based study of kcnh7 p.Arg394his and bipolar spectrum disorder. Hum Mol Genet 23 (23): 6395-6406.
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Product Notes
The KCNH7 (Catalog #AAA8110332) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-KCNH7 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KCNH7 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:200-1:1000. Researchers should empirically determine the suitability of the KCNH7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KCNH7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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