Rabbit anti-Human HPCA Polyclonal Antibody | anti-HPCA antibody

Anti-HPCA Antibody, Rabbit Polyclonal

Cat. Num. AAA8110400

• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: HPCA; Polyclonal Antibody; Anti-HPCA Antibody; Rabbit Polyclonal; HPCA Antibody; Rabbit PAb; Antigen Affinity Purified; hippocalcin; Anti-BDR2 Antibody; Anti-DYT2 Antibody; anti-HPCA antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human HPCA
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-HPCA antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:50-1:200
• Immunogen: E Coli-derived Human HPCA fragment
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with E Coli-derived Human HPCA fragment, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human HPCA in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)

Immunohistochemistry (IHC)

(Immunochemical staining of human HPCA in cynomolgus cerebellum with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-HPCA antibody

Hippocalcin (HPCA) is a neuron-specific calcium-binding protein predominantly expressed in the nervous system. Hippocalcin is a member of the neuronal Ca(2+) sensor protein family. Among its many biochemical functions, its established physiological function is that via neuronal apoptosis inhibitory protein it protects the neurons from Ca(2+)-induced cell death. Hippocalcin is a 193 aa protein that is a member of the neuronal calcium sensor protein family, whose functions are regulated by calcium. Mice that lack the function of this protein are compromised in the long term potentiation aspect of memory generation. Mutations in HPCA gene are linked with dystonia in human. The protein has no intrinsic enzyme activity but is known to bind to variety of target proteins. Hippocalcin is implicated in regulating neuronal viability and plasticity. Hippocalcin is the most highly expressed neuronal calcium sensor in the medium spiny striatal output neurons that degenerate selectively in Huntington's disease (HD).

References

Rudinskiy N, et al. (2009) Diminished hippocalcin expression in huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons. J Neurochem 111 (2): 460-472.Krishnan A, et al. (2009) Hippocalcin, new ca(2+) sensor of a ros-gc subfamily member, one-gc, membrane guanylate cyclase transduction system. Mol Cell Biochem 325 (1-2): 1-14.Koh PO (2013) Nicotinamide attenuates the injury-induced decrease of hippocalcin in ischemic brain injury. Neurosci Lett 545 6-10.