Immunohistochemistry (IHC)
(Immunochemical staining ATP2A2 in human skeletal muscle with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Rabbit ATP2A2 Polyclonal Antibody | anti-ATP2A2 antibody
Anti-ATP2A2 Antibody, Rabbit Polyclonal
Reactivity
Human, Cynomolgus
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
ATP2A2; Polyclonal Antibody; Anti-ATP2A2 Antibody; Rabbit Polyclonal; ATP2A2 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-ATP2B Antibody; Anti-DAR Antibody; Anti-DD Antibody; Anti-SERCA2 Antibody; anti-ATP2A2 antibody
Host
Rabbit
Reactivity
Human, Cynomolgus
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human ATP2A2
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-ATP2A2 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:100-1:400
Immunogen
E Coli-derived Human ATP2A2 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human ATP2A2 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining ATP2A2 in human skeletal muscle with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining ATP2A2 in human skeletal muscle with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining ATP2A2 in cynomolgus heart with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining ATP2A2 in cynomolgus heart with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-ATP2A2 antibody
ATP2A2 encoding the sarcoplasmic/endoplasmic reticulum Ca(2+) -ATPase2 (SERCA2) is a Darier disease (DD)-related gene. Darier disease (DD) is an autosomal dominant skin disease characterized by multiple keratotic papules in the seborrheic regions of the body. Evidence of a population-level association between DD and psychiatric disorders suggests that mutations in ATP2A2 may have pleiotropic effects on the brain as well as skin. The ATP2A2 gene encodes the SERCA protein required for active calcium reuptake to the sarcoplasmic reticulum in cardiac and slow-twitch skeletal muscle. The ATP2A2 rs3026468 variant has been associated with voluntary strength phenotypes in humans. Ultraviolet (UV) B irradiation downregulates ATP2A2/SERCA2 expression in keratinocytes, whereas cyclooxygenase-2 (COX-2) expression is dramatically upregulated by UVB.
References
Liu LH, et al. (2001) Squamous cell tumors in mice heterozygous for a null allele of atp2a2, encoding the sarco(endo)plasmic reticulum ca2+-atpase isoform 2 ca2+ pump. J Biol Chem 276 (29): 26737-26740.Kirk EA, et al. (2019) Atp2a2 rs3026468 does not associate with quadriceps contractile properties and acute muscle potentiation in humans. Physiol Genomics 51 (1): 10-11.Kamijo M, et al. (2012) Cyclooxygenase-2 inhibition restores ultraviolet b-induced downregulation of atp2a2/serca2 in keratinocytes: Possible therapeutic approach of cyclooxygenase-2 inhibition for treatment of darier disease. Br J Dermatol 166 (5): 1017-1022.Gordon-Smith K, et al. (2018) Genotype-phenotype correlations in darier disease: A focus on the neuropsychiatric phenotype. Am J Med Genet B Neuropsychiatr Genet 177 (8): 717-726.
Similar Products
Product Notes
The ATP2A2 (Catalog #AAA8108761) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ATP2A2 Antibody, Rabbit Polyclonal reacts with Human, Cynomolgus and may cross-react with other species as described in the data sheet. AAA Biotech's ATP2A2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:100-1:400. Researchers should empirically determine the suitability of the ATP2A2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ATP2A2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
