Rabbit PPP1R17 Polyclonal Antibody | anti-PPP1R17 antibody

Anti-PPP1R17 Antibody, Rabbit Polyclonal

Cat. Num. AAA8108640

• Reactivity: Human; Predicted to React with: Cynomolgus (Species predicted to react based on 100% sequence homology)
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: PPP1R17; Polyclonal Antibody; Anti-PPP1R17 Antibody; Rabbit Polyclonal; PPP1R17 Antibody; Rabbit PAb; Antigen Affinity Purified; protein phosphatase 1; regulatory subunit 17; Anti-C7orf16 Antibody; Anti-GSBS Antibody; anti-PPP1R17 antibody

• Host: Rabbit
• Reactivity: Human; Predicted to React with: Cynomolgus (Species predicted to react based on 100% sequence homology)
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human PPP1R17
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-PPP1R17 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:200-1:1000
• Immunogen: E Coli-derived Human PPP1R17 fragment
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with E Coli-derived Human PPP1R17 fragment, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human PPP1R17 in cynomolgus cerebellum with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-PPP1R17 antibody

PPP1R17 (Protein Phosphatase 1 Regulatory Subunit 17) is a Protein Coding gene. The PPP1R17 gene, located on 7p14.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for the cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene. Diseases associated with PPP1R17 include Hypercholesterolemia, Familial, 1. The related pathway of PPP1R17 is Long-term depression. 219 organisms have orthologs with the human gene PPP1R17.

References

Hall KU, et al. (1999) Phosphorylation-dependent inhibition of protein phosphatase-1 by g-substrate. A purkinje cell substrate of the cyclic gmp-dependent protein kinase. J Biol Chem 274 (6): 3485-3495.Endo S, et al. (1999) Molecular identification of human g-substrate, a possible downstream component of the cgmp-dependent protein kinase cascade in cerebellar purkinje cells. Proc Natl Acad Sci U S A 96 (5): 2467-2472.Endo S (2012) G-substrate: The cerebellum and beyond. Prog Mol Biol Transl Sci 106 381-416.