Rabbit anti-Human TRPC5 Polyclonal Antibody | anti-TRPC5 antibody
Anti-TRPC5 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
TRPC5; Polyclonal Antibody; Anti-TRPC5 Antibody; Rabbit Polyclonal; TRPC5 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-RP1-68D15.2 Antibody; Anti-TRP5 Antibody; anti-TRPC5 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human TRPC5
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-TRPC5 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human TRPC5 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human TRPC5 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human TRPC5 in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-TRPC5 antibody
Human canonical transient receptor potential channel 5 (TRPC5) gene is located on the Xq23 region of chromosome X. TRPC5 is a Ca(2+)-permeable cation channel predominantly expressed in the CNS, including the hippocampus, cerebellum, amygdala, sensory neurons, and retina. It also shows more restricted expression in the periphery, notably in the kidney and cardiovascular system. Homotetrameric TRPC5 channels are primarily activated by receptors coupled to Gq and phospholipase C and/or Gi proteins, but TRPC5 channels may also gate in a store-dependent manner, which requires other partner proteins such TRPC1, STIM1, and Orai1. There is an impressive array of other activators of TRPC5 channels, such as nitric oxide, lysophospholipids, sphingosine-1-phosphate, reduced thioredoxin, protons, lanthanides, and calcium, and many can cause its direct activation.
References
Zholos AV (2014) Trpc5. Handb Exp Pharmacol 222 129-156.Zhang P, et al. (2017) Trpc5-induced autophagy promotes drug resistance in breast carcinoma via camkkbeta/ampkalpha/mtor pathway. Sci Rep 7 (1): 3158.Li Z, et al. (2017) Trpc5 channel modulates endothelial cells senescence. Eur J Pharmacol 802 27-35.
