Western Blot (WB)
(Western blot analysis of extracts from HeLa cells, using HP1BP3 Antibody. The lane on the left was treated with blocking peptide.)
Rabbit HP1BP3 Polyclonal Antibody | anti-HP1BP3 antibody
HP1BP3 Antibody
Gene Names
HP1BP3; HP1BP74; HP1-BP74
Reactivity
Human, MousePredicted: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Applications
Western Blot
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
HP1BP3; Polyclonal Antibody; HP1BP3 Antibody; Heterochromatin protein 1; binding protein 3; Heterochromatin protein 1-binding protein 3; HP1 BP74; HP1B3_HUMAN; HP1BP 3; MGC28927; MGC43701; MGC72624; OTTHUMP00000002717; OTTHUMP00000002719; OTTHUMP00000002720; Protein HP1 BP74; Protein HP1-BP74; RP5 930J4.3; anti-HP1BP3 antibody
Host
Rabbit
Reactivity
Human, Mouse
Predicted: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Predicted: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Clonality
Polyclonal
Isotype
IgG
Specificity
HP1BP3 Antibody detects endogenous levels of HP1BP3.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
401
Applicable Applications for anti-HP1BP3 antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:2000
Immunogen
A synthesized peptide derived from human HP1BP3.
Fragment
Fab Fragment
Conjugate
Unconjugated
Subcellular Location
Nucleus
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Western blot analysis of extracts from HeLa cells, using HP1BP3 Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from HeLa cells, using HP1BP3 Antibody. The lane on the left was treated with blocking peptide.)
Related Product Information for anti-HP1BP3 antibody
Description: Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860).
Subunit Structure: Interacts (via PxVxL motif) with CBX5 (via Trp-174).
Similarity: A central region that included the first H15 (linker histone H1/H5 globular) domain binds at the entry/exit site of the nucleosomal DNA.
Subunit Structure: Interacts (via PxVxL motif) with CBX5 (via Trp-174).
Similarity: A central region that included the first H15 (linker histone H1/H5 globular) domain binds at the entry/exit site of the nucleosomal DNA.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
Observed: 70 kDa
Predicted: 62 kDa
Predicted: 62 kDa
NCBI Official Full Name
HP1BP3 protein
NCBI Official Synonym Full Names
heterochromatin protein 1 binding protein 3
NCBI Official Symbol
HP1BP3
NCBI Official Synonym Symbols
HP1BP74; HP1-BP74
NCBI Protein Information
heterochromatin protein 1-binding protein 3
UniProt Protein Name
Heterochromatin protein 1-binding protein 3
Protein Family
UniProt Gene Name
HP1BP3
UniProt Entry Name
HP1B3_HUMAN
Uniprot Description
HP1BP3: Component of heterochromatin, may be involved in chromatin structure and function. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component: nucleosome; chromosome; nucleus
Molecular Function: protein binding; DNA binding; nucleosome binding
Biological Process: nucleosome assembly; regulation of transcription, DNA-dependent; regulation of cell proliferation
Research Articles on HP1BP3
Similar Products
Product Notes
The HP1BP3 hp1bp3 (Catalog #AAA9611821) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HP1BP3 Antibody reacts with Human, Mouse Predicted: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken and may cross-react with other species as described in the data sheet. AAA Biotech's HP1BP3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the HP1BP3 hp1bp3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HP1BP3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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