Western Blot (WB)
(Western blot analysis of extracts from Human skeletal muscle tissue, using IL1RAPL1 Antibody. The lane on the left was treated with blocking peptide.)
Rabbit IL1RAPL1 Polyclonal Antibody | anti-IL1RAPL1 antibody
IL1RAPL1 Antibody
Predicted: Chicken
Predicted: Chicken
Western Blot (WB)
(Western blot analysis of extracts from Human skeletal muscle tissue, using IL1RAPL1 Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from Human skeletal muscle tissue, using IL1RAPL1 Antibody. The lane on the left was treated with blocking peptide.)
Subunit Structure: Homodimer (PubMed:15123616). Interacts (calcium-independent) with NCS1 (PubMed:12783849). Interacts (via the first immunoglobilin domain) with PTPRD (via the second immunoglobilin domain); this interaction is PTPRD-splicing-dependent and induces pre- and post-synaptic differentiation of neurons and is required for IL1RAPL1-mediated synapse formation (By similarity).
Similarity: Belongs to the interleukin-1 receptor family.
NCBI and Uniprot Product Information
Predicted: 80 kDa
NCBI Description
The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signalling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization. [provided by RefSeq, Jul 2017]
Uniprot Description
IL1RAPL1: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons. Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the interleukin-1 receptor family. 1 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: Xp22.1-p21.3
Cellular Component: postsynaptic membrane; cell surface; axon; cytoplasm; dendrite; plasma membrane; integral to membrane
Molecular Function: voltage-gated calcium channel activity; protein binding; interleukin-1 binding; receptor binding
Biological Process: heterophilic cell adhesion; neuron differentiation; negative regulation of exocytosis; positive regulation of dendrite morphogenesis; signal transduction
Disease: Mental Retardation, X-linked 21
Research Articles on IL1RAPL1
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Product Notes
The IL1RAPL1 il1rapl1 (Catalog #AAA9611838) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IL1RAPL1 Antibody reacts with Human, Mouse, Rat Predicted: Chicken and may cross-react with other species as described in the data sheet. AAA Biotech's IL1RAPL1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the IL1RAPL1 il1rapl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL1RAPL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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