Rabbit anti-Human GSK3A / GSK3 Alpha Polyclonal Antibody | anti-GSK3A antibody

Rabbit Polyclonal to Human GSK3A / GSK3 Alpha

Cat. Num. AAA248562

• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Ammonium sulfate precipitation
• Synonyms: GSK3A / GSK3 Alpha; Polyclonal Antibody; Rabbit Polyclonal to Human GSK3A / GSK3 Alpha; Anti-GSK3A / GSK3 Alpha Antibody (aa448-478) IHC-plus; GSK3A; GSK-3 alpha; GSK3 alpha; Human GSK3A; GSK3 Alpha; anti-GSK3A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Ammonium sulfate precipitation
• Form/Format: PBS, 0.09% sodium azide
• Sequence Length: 483

• Applicable Applications for anti-GSK3A antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (1:75), WB (1:1000)
• Target Species: Human
• Immunogen Description: KLH conjugated synthetic peptide selected from the C-terminal region of human GSK3A.
• Immunogen Type: Synthetic peptide
• Immunogen: GSK3A / GSK3 Alpha antibody was raised against kLH conjugated synthetic peptide selected from the C-terminal region of human GSK3A.
• Antigen Modification: aa448-478
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Immunohistochemistry (IHC)

(Anti-GSK3A / GSK3 Alpha antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.)

Western Blot (WB)

(Western blot of GSK3A (arrow) using GSK3A Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GSK3A gene (Lane 2).)

Western Blot (WB)

(GSK3A Antibody (C-term) western blot analysis in A549 cell line lysates (35 ug/lane).This demonstrates the GSK3A antibody detected the GSK3A protein (arrow).)

Related Product Information for anti-GSK3A antibody

Glycogen Synthase Kinase 3 Alpha is a GSK-3 multisubstrate serine/threonine kinase. Improper phosphorylation by Glycogen Synthase Kinase 3 Alpha has been implicated in Alzheimer's Disease.

Product Categories/Family for anti-GSK3A antibody

Family: Protein Kinase; Subfamily: GSK-3

NCBI and Uniprot Product Information

• NCBI GI #: 49574532
• NCBI GeneID: 2931
• NCBI Accession #: NP_063937.2
• NCBI GenBank Nucleotide #: NM_019884.2
• UniProt Accession #: P49840; O14959
• Molecular Weight: 50,981 Da
• NCBI Official Full Name: glycogen synthase kinase-3 alpha
• NCBI Official Synonym Full Names: glycogen synthase kinase 3 alpha
• NCBI Official Symbol: GSK3A
• NCBI Protein Information: glycogen synthase kinase-3 alpha; GSK-3 alpha; serine/threonine-protein kinase GSK3A
• UniProt Protein Name: Glycogen synthase kinase-3 alpha
• Protein Family: Glycogen synthase kinase
• UniProt Gene Name: GSK3A
• UniProt Synonym Gene Names: GSK-3 alpha
• UniProt Entry Name: GSK3A_HUMAN

NCBI Description

This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]

Uniprot Description

GSK3A: a proline-directed protein kinase of the GSK family. Implicated in the control of several regulatory proteins including glycogen synthase, Myb, and c-Jun. GSK3 and GSK3 have similar functions. GSK3 phophorylates tau, the principal component of neurofibrillary tangles in Alzheimer disease and is required for maximal production of amyloid plaque peptides by secretase. A GSK3 promoter SNP effects progression of bipolar disorder. The GSK3 inhibitor, lithium, is used to treat bipolar disorder and is seen to block plaque formation. GSK3 generally opposes the action of insulin, and GSK3 hyperactivity is thought to contribute to insulin resistant (type II) diabetes. GSK3 also negatively regulates cardiac hypertrophy. A tumor suppressor role is indicated by the oncogenic potential of stabilized -catenin mutants that lack GSK3 phosphorylation sites. Inhibitor: AR-A014418

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.26; EC 2.7.11.1; Protein kinase, CMGC; CMGC group; GSK family; GSK subfamily

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: beta-catenin destruction complex; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; tau-protein kinase activity; ATP binding

Biological Process: glycogen metabolic process; proteasomal ubiquitin-dependent protein catabolic process; genetic imprinting; nerve growth factor receptor signaling pathway; negative regulation of insulin receptor signaling pathway; protein amino acid phosphorylation; negative regulation of transferase activity; positive regulation of cAMP biosynthetic process; negative regulation of glycogen biosynthetic process; epidermal growth factor receptor signaling pathway; nervous system development; negative regulation of TOR signaling pathway; cell migration; fibroblast growth factor receptor signaling pathway; Wnt receptor signaling pathway; phosphoinositide-mediated signaling; unfolded protein response; positive regulation of peptidyl-serine phosphorylation; negative regulation of glucose import; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; cellular response to insulin stimulus; positive regulation of protein catabolic process; insulin receptor signaling pathway; regulation of systemic arterial blood pressure; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of heart contraction