Rabbit GABAA Receptor beta1 Polyclonal Antibody | anti-GABRB1 antibody

GABAA Receptor beta1

Cat. Num. AAA500056

• Gene Names: Gabrb1; GARB1
• Reactivity: Bovine, Canine, Chicken, Human, Non-Human primate Xenopus, Zebra fish; Predicted: Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified from Pooled Serum
• Synonyms: GABAA Receptor beta1; Polyclonal Antibody; anti-GABRB1 antibody

• Host: Rabbit
• Reactivity: Bovine, Canine, Chicken, Human, Non-Human primate Xenopus, Zebra fish; Predicted: Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity Purified from Pooled Serum
• Form/Format: 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol.
• Sequence Length: 474

• Applicable Applications for anti-GABRB1 antibody: Western Blot (WB)
• Application Notes: WB: 1:1,000
• Immunogen: Fusion protein from the cytoplasmic loop of the beta 1 subunit; Immunogen Species
• Purification Note: The antibody is prepared from pooled rabbit serum by affinity purification using a column to which the fusion protein immunogen was coupled.
• Preparation and Storage: Store at -20 degree C

Related Product Information for anti-GABRB1 antibody

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha- subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003).

Product Categories/Family for anti-GABRB1 antibody

GABA Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 6978867
• NCBI GeneID: 25450
• NCBI Accession #: NP_037088.1
• NCBI GenBank Nucleotide #: NM_012956.1
• UniProt Accession #: P15431
• Molecular Weight: ~55 kDa
• NCBI Official Full Name: gamma-aminobutyric acid receptor subunit beta-1
• NCBI Official Synonym Full Names: gamma-aminobutyric acid type A receptor beta 1 subunit
• NCBI Official Symbol: Gabrb1
• NCBI Official Synonym Symbols: GARB1
• NCBI Protein Information: gamma-aminobutyric acid receptor subunit beta-1
• UniProt Protein Name: Gamma-aminobutyric acid receptor subunit beta-1
• Protein Family: Gamma-aminobutyric acid receptor
• UniProt Gene Name: Gabrb1
• UniProt Synonym Gene Names: Gabrb-1

NCBI Description

subunit of GABAA receptors,which induce inhibitory postsynaptic currents; may regulate synaptic transmission in the prefrontal cortex [RGD, Feb 2006]

Uniprot Description

GABRB1: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily.

Protein type: Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 14p11

Cellular Component: cytoplasm; dendrite; integral to plasma membrane; membrane; nuclear envelope; nucleus; plasma membrane; receptor complex

Molecular Function: anion channel activity; GABA receptor binding; GABA-A receptor activity; GABA-gated chloride ion channel activity; ligand-gated ion channel activity

Biological Process: central nervous system neuron development; chloride transport; gamma-aminobutyric acid signaling pathway; ion transport; ovulation cycle; response to progesterone stimulus; response to toxin