Rabbit anti-Human GABA Receptor A, alpha1 Polyclonal Antibody | anti-GABRB1 antibody

GABA Receptor A, alpha1 (Gamma-aminobutyric Acid Receptor Type A alpha 1 Subunit, GABRA1, ECA4, EJM)

Cat. Num. AAA6011564

• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Supernatant; Supernatant
• Synonyms: GABA Receptor A; alpha1; Polyclonal Antibody; alpha1 (Gamma-aminobutyric Acid Receptor Type A alpha 1 Subunit; GABRA1; ECA4; EJM); Anti -GABA Receptor A; anti-GABRB1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human GABRA1.
• Purity/Purification: Supernatant; Supernatant
• Form/Format: Supplied as a lyophilized powder. Reconstitute with sterile dH2O.

• Applicable Applications for anti-GABRB1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot and Immunohistochemistry.; Dilution: Western Blot: 1:500-1:5000; Immunohistochemistry (Paraffin): 10ug/ml
• Immunogen: Synthetic peptide corresponding tohuman GABRA1.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Immunohistochemistry (IHC)

(GABRA1(10ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human brain, cortex, followed by biotinylated goat-rabbit IgG secondary, alkaline phosphatase-streptavidin and chromogen.)

Related Product Information for anti-GABRB1 antibody

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABA-A receptor subtype. GABA-A receptors are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A receptor is a multimeric subunit complex. To date six alpha, four beta, and four gamma subunits, plus alternative splicing variants of some of these subunits, have been identified. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor.

Product Categories/Family for anti-GABRB1 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 194097327
• NCBI GeneID: 2560
• NCBI Accession #: NP_000803.2
• NCBI GenBank Nucleotide #: NM_000812.3
• UniProt Accession #: P18505; Q16166; Q8TBK3; B2R6U7
• Molecular Weight: 54,235 Da
• NCBI Official Full Name: gamma-aminobutyric acid receptor subunit beta-1
• NCBI Official Synonym Full Names: gamma-aminobutyric acid (GABA) A receptor, beta 1
• NCBI Official Symbol: GABRB1
• NCBI Protein Information: gamma-aminobutyric acid receptor subunit beta-1; GABA(A) receptor, beta 1; GABA(A) receptor subunit beta-1
• UniProt Protein Name: Gamma-aminobutyric acid receptor subunit beta-1
• Protein Family: Gamma-aminobutyric acid receptor
• UniProt Gene Name: GABRB1
• UniProt Entry Name: GBRB1_HUMAN

NCBI Description

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008]

Uniprot Description

GABRB1: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily.

Protein type: Channel, chloride; Channel, ligand-gated; Transporter; Membrane protein, integral; Transporter, ion channel; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4p12

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function: chloride channel activity; GABA-A receptor activity; ligand-gated ion channel activity; extracellular ligand-gated ion channel activity

Biological Process: synaptic transmission; transport; ion transport; signal transduction; transmembrane transport