Rabbit flip (I-flICE) (flICE Inhibitory Protein) Polyclonal Antibody | anti-Casp8ap2 antibody

flip (NT) (I-flICE) (flICE Inhibitory Protein)

Cat. Num. AAA395625

• Gene Names: Casp8ap2; FLASH; AA387232; mKIAA1315; D4Ertd659e
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Antigen Immunoaffiinity Purification
• Synonyms: flip (I-flICE) (flICE Inhibitory Protein); Polyclonal Antibody; flip (NT) (I-flICE) (flICE Inhibitory Protein); Anti-FLICE-Inhibitory Protein (N-terminal); Anti-I-FLICE (N-terminal); anti-Casp8ap2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Immunoaffiinity Purification
• Form/Format: Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative
• Sequence Length: 1962

• Applicable Applications for anti-Casp8ap2 antibody: Western Blot (WB)
• Immunogen: Antibody raised against a synthetic peptide corresponding to amino acids 2 to 18 of the human FLIP protein. This sequence is identical in all known FLIP splice variants.
• Preparation and Storage: Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Related Product Information for anti-Casp8ap2 antibody

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively1,2. The human FLIP was also cloned by several labs independently and termed Casper, I-FLICE, FLAME-1, CASH and CLARP3-7. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and ?10, and potently inhibits apoptosis induced by all known death receptors. Four splice variants of c-FLIPs have been identified and termed FLIP,,, and, respectively8.

Product Categories/Family for anti-Casp8ap2 antibody

Polyclonal Antibody; Inhibitors of Apoptosis

NCBI and Uniprot Product Information

• NCBI GI #: 172072595
• NCBI GeneID: 26885
• NCBI Accession #: NP_001116450.1
• NCBI GenBank Nucleotide #: NM_001122978.1
• UniProt Accession #: Q9WUF3; Q9CSW2; B1AX74
• Molecular Weight: 55
• NCBI Official Full Name: CASP8-associated protein 2
• NCBI Official Synonym Full Names: caspase 8 associated protein 2
• NCBI Official Symbol: Casp8ap2
• NCBI Official Synonym Symbols: FLASH; AA387232; mKIAA1315; D4Ertd659e
• NCBI Protein Information: CASP8-associated protein 2; FLICE-associated huge protein
• UniProt Protein Name: CASP8-associated protein 2
• Protein Family: CASP8-associated protein
• UniProt Gene Name: Casp8ap2
• UniProt Synonym Gene Names: Flash
• UniProt Entry Name: C8AP2_MOUSE

Uniprot Description

Function: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation

By similarity. Required for histone gene transcription and progression through S phase

By similarity. Required for histone gene transcription and S phase progression

By similarity. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Ref.1 Ref.5 Ref.6 UniProtKB Q9UKL3

Subunit structure: Self-associates. Interacts with NPAT

By similarity. Interacts with SRRT

By similarity. Interacts (via SIM domains) with SUMO1 and SUMO2

By similarity. Interacts with SP100; may negatively regulate CASP8AP2 export from the nucleus to the cytoplasm

By similarity. Interacts with NCOA2 and NCOA3

By similarity. Component of the death-inducing signaling complex (DISC) with CASP8, FADD and FAS. Interacts with TRAF2. Ref.1 Ref.5 Ref.8

Subcellular location: Cytoplasm

By similarity. Nucleus. Nucleus › PML body

By similarity. Mitochondrion

By similarity. Note: Exported from the nucleus to the mitochondria upon FAS activation

By similarity. Ref.7

Tissue specificity: Highly expressed in heart, brain, thymus, lung, testis and spleen. Ref.1