Rabbit anti-Human FGF-5 Polyclonal Antibody | anti-FGF-5 antibody

FGF-5 Polyclonal Antibody

Cat. Num. AAA9409122

• Gene Names: FGF5; HBGF-5; TCMGLY; Smag-82
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: FGF-5; Polyclonal Antibody; FGF-5 Polyclonal Antibody; FGF5; Fibroblast growth factor 5; Heparin-binding growth factor 5; HBGF-5; Smag-82; anti-FGF-5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: FGF-5 Polyclonal Antibody detects endogenous levels of FGF-5 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 268

• Applicable Applications for anti-FGF-5 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: Western Blot: 1:500 - 1:2000; ELISA: 1:20000; Not yet tested in other applications.
• Immunogen Type: peptide
• Immunogen Description: Synthesized peptide derived from the C-terminal region of human FGF-5.
• Target Name: FGF-5
• Preparation and Storage: Store at -20 degree C/1 year

Western Blot (WB)

(Western Blot analysis of mouse liver cells using FGF-5 Polyclonal Antibody)

Product Categories/Family for anti-FGF-5 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 73486655
• NCBI GeneID: 2250
• NCBI Accession #: NP_004455.2
• NCBI GenBank Nucleotide #: NM_004464.3
• UniProt Accession #: P12034; O75846; Q3Y8M3; Q8NF90; B2R554
• Molecular Weight: 13,006 Da
• NCBI Official Full Name: fibroblast growth factor 5 isoform 1
• NCBI Official Synonym Full Names: fibroblast growth factor 5
• NCBI Official Symbol: FGF5
• NCBI Official Synonym Symbols: HBGF-5; TCMGLY; Smag-82
• NCBI Protein Information: fibroblast growth factor 5
• UniProt Protein Name: Fibroblast growth factor 5
• UniProt Gene Name: FGF5
• UniProt Synonym Gene Names: FGF-5; HBGF-5
• UniProt Entry Name: FGF5_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

FGF5: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Cytokine; Secreted; Oncoprotein

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; cell proliferation; nervous system development; phosphoinositide-mediated signaling; glial cell differentiation; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; cell-cell signaling; positive regulation of cell division; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response

Disease: Trichomegaly