Rabbit FGF5 Polyclonal Antibody | anti-FGF5 antibody

Anti-FGF5 Antibody

Cat. Num. AAA821862

• Gene Names: FGF5; HBGF-5; TCMGLY; Smag-82
• Reactivity: Human, Monkey
• Applications: Western Blot
• Purity: The antibody was purified by immunogen affinity chromatography.
• Synonyms: FGF5; Polyclonal Antibody; Anti-FGF5 Antibody; Fibroblast growth factor 5; FGF-5; Heparin-binding growth factor 5; HBGF-5; Smag-82; anti-FGF5 antibody

• Host: Rabbit
• Reactivity: Human, Monkey
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of FGF5 protein.
• Purity/Purification: The antibody was purified by immunogen affinity chromatography.
• Form/Format: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
• Sequence Length: 268

• Applicable Applications for anti-FGF5 antibody: Western Blot (WB)
• Application Notes: WB (1/500 - 1/1000)
• Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human FGF5. The exact sequence is proprietary.
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of FGF5 expression in A375 (A), NIH3T3 (B) whole cell lysates.)

Related Product Information for anti-FGF5 antibody

Rabbit polyclonal antibody to FGF5

NCBI and Uniprot Product Information

• NCBI GI #: 73486655
• NCBI GeneID: 2250
• NCBI Accession #: NP_004455.2
• NCBI GenBank Nucleotide #: NM_004464.3
• UniProt Accession #: P12034; O75846; Q3Y8M3; Q8NF90; B2R554
• Molecular Weight: 13,006 Da
• NCBI Official Full Name: fibroblast growth factor 5 isoform 1
• NCBI Official Synonym Full Names: fibroblast growth factor 5
• NCBI Official Symbol: FGF5
• NCBI Official Synonym Symbols: HBGF-5; TCMGLY; Smag-82
• NCBI Protein Information: fibroblast growth factor 5; heparin-binding growth factor 5
• UniProt Protein Name: Fibroblast growth factor 5
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF5
• UniProt Synonym Gene Names: FGF-5; HBGF-5
• UniProt Entry Name: FGF5_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

FGF5: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; nervous system development; cell proliferation; glial cell differentiation; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; cell-cell signaling; positive regulation of cell division; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response

Disease: Trichomegaly