Rabbit ERO1 Polyclonal Antibody | anti-ERO1 antibody
ERO1 (ERO1-Lalpha, Oxidoreductin-1-Lalpha, Endoplasmic Oxidoreductin-1-like Protein, ERO1-L)
Gene Names
ERO1; AERO1; endoplasmic reticulum oxidoreductins 1; ERO1; T9N14.18; T9N14_18
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
ERO1; Polyclonal Antibody; ERO1 (ERO1-Lalpha; Oxidoreductin-1-Lalpha; Endoplasmic Oxidoreductin-1-like Protein; ERO1-L); Anti -ERO1 (ERO1-Lalpha; anti-ERO1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
Recognizes human, mouse, and rat ERO1
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Borate buffered saline + 1% BSA
Applicable Applications for anti-ERO1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Suitable for use in Western Blot and Immunohistochemistry.
Immunogen
A synthetic peptide made the the N-terminal region of the human protein. [UniProt Q96HE7].
Positive Control
293T, INS-1, and MIN6 cell lysates.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-ERO1 antibody
Perhaps the most distinctive feature of protein folding in the ER is the abundance of disulfide bonds that must form during maturation of proteins traveling along the secretory pathway. Formation of disulfide bonds is a redox reaction. Thus, to match the flux of disulfide bonds that exit from the ER by virtue of protein secretion, a flux of oxidizing equivalents into the ER is required. In eukaryotic cells, the essential protein relay supporting this flux, and hence disulfide bond formation, involves endoplasmic reticulum oxidoreductin 1 (Ero1) and protein disulfide isomerase (PDI). The temporal pattern of hypoxic ERO1-L alpha induction is very similar to that of genes triggered by the hypoxia inducible transcription factor (HIF-1) and is characteristically mimicked by cobalt and by deferoxamine, but is absent in cells with a defective aryl hydrocarbon receptor translocator (ARNT, HIF-1 alpha). We speculate from these findings that the expression of ERO1-L alpha is probably regulated via the HIF-pathway and thus belongs to the family of classic oxygen regulated genes.
Product Categories/Family for anti-ERO1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
endoplasmic oxidoreductin-1
NCBI Official Symbol
ERO1
NCBI Official Synonym Symbols
AERO1; endoplasmic reticulum oxidoreductins 1; ERO1; T9N14.18; T9N14_18
NCBI Protein Information
endoplasmic oxidoreductin-1
Protein Family
NCBI Description
endoplasmic reticulum oxidoreductin
Similar Products
Product Notes
The ERO1 (Catalog #AAA616109) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ERO1 (ERO1-Lalpha, Oxidoreductin-1-Lalpha, Endoplasmic Oxidoreductin-1-like Protein, ERO1-L) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ERO1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Western Blot and Immunohistochemistry. Researchers should empirically determine the suitability of the ERO1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ERO1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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