Immunohistochemistry (IHC)
(Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Human DRAK2 Polyclonal Antibody
DRAK2, CT (Serine/Threonine-protein Kinase 17B, DAP Kinase-related Apoptosis-inducing Protein Kinase 2, STK17B)
Reactivity
Human
Applications
Immunohistochemistry
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
DRAK2; Polyclonal Antibody; CT (Serine/Threonine-protein Kinase 17B; DAP Kinase-related Apoptosis-inducing Protein Kinase 2; STK17B); Anti -DRAK2; anti-DRAK2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human STK17B.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in 10mM PBS, pH 7.4, BSA, sodium azide.
Applicable Applications for anti-DRAK2 antibody
Immunohistochemistry (IHC)
Application Notes
Suitable for use in mmunohistochemistry.
Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 1:50
Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 1:50
Immunogen
Synthetic peptide corresponding to human DRAK2 at C-terminal.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunohistochemistry (IHC)
(Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry (IHC)
(Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
Related Product Information for anti-DRAK2 antibody
Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase-related apoptosis-inducing protein kinases). DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK2 induces apoptosis. DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissue. STK17B, a DAPK type protein kinase, functions in apoptotic signaling. In vitro assays have shown that protein is autophosphorylated. Messanger RNAs of various in sizes have been reported, likely due to differences of 3' untranslated region.
Product Categories/Family for anti-DRAK2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI Official Full Name
DRAK2
Uniprot Description
DRAK2: a calmodulin-dependent kinase of the DAPK family. Interacts with and is regulated by calcineurin homologous protein (CHP), an EF-hand Ca(2+)-binding protein. In vitro, CHP inhibits the apoptosis-inducing protein kinase DRAK2 in the presence of elevated Ca(2+) levels. Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.
Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; CAMK group; DAPK family
Chromosomal Location of Human Ortholog: 2q32.3
Cellular Component: plasma membrane; ER-Golgi intermediate compartment; nucleus; actin cytoskeleton
Molecular Function: protein serine/threonine kinase activity; ATP binding; protein kinase activity
Biological Process: apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation
Similar Products
Product Notes
The DRAK2 (Catalog #AAA644760) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DRAK2, CT (Serine/Threonine-protein Kinase 17B, DAP Kinase-related Apoptosis-inducing Protein Kinase 2, STK17B) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DRAK2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Suitable for use in mmunohistochemistry. Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 1:50. Researchers should empirically determine the suitability of the DRAK2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DRAK2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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