Rabbit anti-Human DRAK2 Polyclonal Antibody | anti-STK17B antibody

DRAK2 Antibody

Cat. Num. AAA151387

• Gene Names: STK17B; DRAK2
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunocytochemistry
• Purity: DRAK2 Antibody is Ion exchange chromatography purified.
• Synonyms: DRAK2; Polyclonal Antibody; DRAK2 Antibody; DAP kinase-related apoptosis-inducing protein kinase 2; serine/threonine kinase 17b; anti-STK17B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: It has no cross responses to DAP or ZIP kinases. The approximately 70 kDa band is probably non-related to DRAK2 although it is peptide blockable.
• Purity/Purification: DRAK2 Antibody is Ion exchange chromatography purified.
• Form/Format: Liquid
• Sequence Length: 1627

• Applicable Applications for anti-STK17B antibody: ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
• Application Notes: DRAK2 antibody can be used for detection of DRAK2 by Western blot 0.5 mug/mL. An approximately 45 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 mug/mL.
• Conjugate: Unconjugated
• Immunogen: DRAK2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human DRAK2.
• Buffer: DRAK2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: DRAK2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of DRAK2 in Raji cell lysate with DRAK2 antibody at (A) 1 and B (2) μg/mL.)

Immunocytochemistry (IHC)

(Immunocytochemistry of DRAK2 in Jurkat cells with DRAK2 antibody at 10 μg/mL.)

Related Product Information for anti-STK17B antibody

DRAK2 Antibody: Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase-related apoptosis-inducing protein kinases). DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK2 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.

NCBI and Uniprot Product Information

• NCBI GI #: 3834355
• NCBI GeneID: 9262
• UniProt Accession #: O94768
• Molecular Weight: 42,344 Da
• NCBI Official Full Name: Homo sapiens mRNA for DRAK2, complete cds
• NCBI Official Synonym Full Names: serine/threonine kinase 17b
• NCBI Official Symbol: STK17B
• NCBI Official Synonym Symbols: DRAK2
• NCBI Protein Information: serine/threonine-protein kinase 17B; death-associated protein kinase-related 2; DAP kinase-related apoptosis-inducing protein kinase 2
• UniProt Protein Name: Serine/threonine-protein kinase 17B
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: STK17B
• UniProt Synonym Gene Names: DRAK2
• UniProt Entry Name: ST17B_HUMAN

Uniprot Description

DRAK2: a calmodulin-dependent kinase of the DAPK family. Interacts with and is regulated by calcineurin homologous protein (CHP), an EF-hand Ca(2+)-binding protein. In vitro, CHP inhibits the apoptosis-inducing protein kinase DRAK2 in the presence of elevated Ca(2+) levels. Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; CAMK group; DAPK family

Chromosomal Location of Human Ortholog: 2q32.3

Cellular Component: plasma membrane; ER-Golgi intermediate compartment; nucleus; actin cytoskeleton

Molecular Function: protein serine/threonine kinase activity; ATP binding; protein kinase activity

Biological Process: apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation