IL-34 Blocking Peptide | IL34 blocking peptide

IL-34 Peptide

Cat. Num. AAA152753

• Gene Names: IL34; IL-34; C16orf77
• Applications: Blocking (BL)
• Synonyms: IL-34; IL-34 Peptide; C16orf77; Interleukin-34; interleukin 34; IL34 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 241

• Applicable Applications for IL34 blocking peptide: Blocking (BL)
• Application Notes: IL-34 peptide is used for blocking the activity of IL-34 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 16 amino acids near the amino terminus of human IL-34
• Preparation and Storage: Store IL-34 peptide at -20 degree C, stable for one year.

Western Blot (WB)

(Western blot analysis of IL-34 in human brain tissue lysate with IL-34 antibody at 0.25 μg/mL in (A) the absence and (B) the presence of blocking peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 187610438
• NCBI GeneID: 146433
• UniProt Accession #: Q6ZMJ4; Q8N6L2; B2RC28; B2Z4A8; B2ZC70
• Molecular Weight: 27,354 Da
• NCBI Official Full Name: interleukin 34 isoform 1
• NCBI Official Synonym Full Names: interleukin 34
• NCBI Official Symbol: IL34
• NCBI Official Synonym Symbols: IL-34; C16orf77
• NCBI Protein Information: interleukin-34
• UniProt Protein Name: Interleukin-34
• Protein Family: Interleukin
• UniProt Gene Name: IL34
• UniProt Synonym Gene Names: C16orf77; IL-34
• UniProt Entry Name: IL34_HUMAN

NCBI Description

Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]

Uniprot Description

IL34: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Belongs to the IL-34 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Cell cycle regulation; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: extracellular space

Molecular Function: growth factor activity; cytokine activity; macrophage colony stimulating factor receptor binding

Biological Process: positive regulation of cell proliferation; innate immune response; positive regulation of protein amino acid phosphorylation; inflammatory response