Testing Data
Rabbit DKK4 Polyclonal Antibody | anti-DKK4 antibody
DKK4 Antibody
Gene Names
Dkk4; Dkk-4
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
Affinity purified
Synonyms
DKK4; Polyclonal Antibody; DKK4 Antibody; DKK-4; DKK 4; dkk4; dkk-4; dkk 4; dickkopf homolog-4; dickkopf homolog4; dickkopf homolog 4; anti-DKK4 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity purified
Form/Format
100 ug (0.5 mg/ml) antigen affinity purified rabbit anti-Dkk4 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% Thimerosal.
Appearance: Colorless liquid
Appearance: Colorless liquid
Concentration
0.5 mg/ml (varies by lot)
Sequence Length
221
Applicable Applications for anti-DKK4 antibody
Western Blot (WB)
Application Notes
Western blotting (0.5-4 ug/ml). However, the optimal conditions should be determined individually. The antibody detects ~40 kDa of Dkk4 in samples from human, mouse and rat origins. Reactivity to other species has not been determined.
Immunogen
Synthetic peptide surrounding amino acid 179 of mouse Dkk4
Handling
The antibody solution should be gently mixed before use.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Shelf Life: 12 months
Testing Data
Testing Data
Related Product Information for anti-DKK4 antibody
Background: Xenopus Dickkopf (Dkk) was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of Dkk have been identified in mammals. Each Dkk molecule contains two conserved cysteine-rich domains which are separated by a 50-55 amino acid linker region. Dkk4 is a secreted glycoprotein and has three immune-reactive sites at 15-17kDa, 30-32kDa and at 40kDa.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
24,261 Da
NCBI Official Full Name
dickkopf-related protein 4
NCBI Official Synonym Full Names
dickkopf homolog 4 (Xenopus laevis)
NCBI Official Symbol
Dkk4
NCBI Official Synonym Symbols
Dkk-4
NCBI Protein Information
dickkopf-related protein 4
UniProt Protein Name
Dickkopf-related protein 4
Protein Family
UniProt Gene Name
Dkk4
UniProt Synonym Gene Names
Dickkopf-4; Dkk-4
UniProt Entry Name
DKK4_MOUSE
Uniprot Description
DKK4: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Belongs to the dickkopf family.
Protein type: Secreted; Inhibitor; Secreted, signal peptide
Cellular Component: extracellular region
Biological Process: Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; multicellular organismal development
Research Articles on DKK4
Similar Products
Product Notes
The DKK4 dkk4 (Catalog #AAA840247) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DKK4 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's DKK4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting (0.5-4 ug/ml). However, the optimal conditions should be determined individually. The antibody detects ~40 kDa of Dkk4 in samples from human, mouse and rat origins. Reactivity to other species has not been determined. Researchers should empirically determine the suitability of the DKK4 dkk4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DKK4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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