Rabbit anti-Human DBH Polyclonal Antibody | anti-DBH antibody

DBH Antibody

Cat. Num. AAA9402428

• Gene Names: DBH; DBM
• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: DBH; Polyclonal Antibody; DBH Antibody; Dopamine beta-hydroxylase; Dopamine beta-monooxygenase; anti-DBH antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total DBH protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 617

• Applicable Applications for anti-DBH antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500~1:3000
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human DBH.
• Target Name: DBH
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts from Jurkat cells, using DBH antibody.)

Related Product Information for anti-DBH antibody

Conversion of dopamine to noradrenaline.Dunham I., Nature 429:369-374(2004).Kim K.-S., Am. J. Med. Genet. 108:140-147(2002).Lander E.S., Nat. Genet. 23:373-373(1999).

Product Categories/Family for anti-DBH antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 116534900
• NCBI GeneID: 1621
• NCBI Accession #: NP_000778.3
• NCBI GenBank Nucleotide #: NM_000787.3
• UniProt Accession #: P09172; Q5T381; Q96AG2
• Molecular Weight: 69,065 Da
• NCBI Official Full Name: dopamine beta-hydroxylase
• NCBI Official Synonym Full Names: dopamine beta-hydroxylase (dopamine beta-monooxygenase)
• NCBI Official Symbol: DBH
• NCBI Official Synonym Symbols: DBM
• NCBI Protein Information: dopamine beta-hydroxylase
• UniProt Protein Name: Dopamine beta-hydroxylase
• Protein Family: Dopamine beta-hydroxylase
• UniProt Gene Name: DBH
• UniProt Entry Name: DOPO_HUMAN

NCBI Description

The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq, Jul 2008]

Uniprot Description

DBH: Conversion of dopamine to noradrenaline. Homotetramer composed of two non-covalently bound disulfide-linked dimers. Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids. Belongs to the copper type II ascorbate-dependent monooxygenase family.

Protein type: Apoptosis; Oxidoreductase; Cell cycle regulation; EC 1.14.17.1; Motility/polarity/chemotaxis; Membrane protein, integral; Amino Acid Metabolism - tyrosine

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: membrane; cytoplasm; integral to membrane; extracellular region

Molecular Function: copper ion binding; L-ascorbic acid binding; dopamine beta-monooxygenase activity; catalytic activity

Biological Process: fear response; dopamine catabolic process; maternal behavior; response to amphetamine; cytokine production; locomotory behavior; response to pain; behavioral response to ethanol; leukocyte mediated immunity; glucose homeostasis; memory; regulation of cell proliferation; norepinephrine biosynthetic process; synaptic transmission; catecholamine biosynthetic process; homoiothermy; positive regulation of vasoconstriction; visual learning; blood vessel remodeling; leukocyte migration

Disease: Dopamine Beta-hydroxylase Deficiency, Congenital