Western Blot (WB)
(CSEN polyclonal antibody. Western Blot analysis of CSEN expression in rat brain.)
Mouse anti-Human, Rat CSEN Polyclonal Antibody | anti-KCNIP3 antibody
CSEN (Calsenilin, Kv Channel-interacting Protein 3, A-type Potassium Channel Modulatory Protein 3, DRE-antagonist Modulator, DREAM, KCNIP3, KChIP3, MGC18289)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(CSEN polyclonal antibody. Western Blot analysis of CSEN expression in rat brain.)
Western Blot (WB)
(CSEN polyclonal antibody. Western Blot analysis of CSEN expression in rat brain.)
Western Blot (WB)
(Western Blot analysis of KCNIP3 expression in transfected 293T cell line by KCNIP3 polyclonal antibody. Lane 1: CSEN transfected lysate (28.16kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of KCNIP3 expression in transfected 293T cell line by KCNIP3 polyclonal antibody. Lane 1: CSEN transfected lysate (28.16kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception
By similarity. Ref.1 Ref.2 Ref.3 Ref.12 Ref.13 Ref.14Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and probably KCND3 trafficking to the cell surface. Ref.1 Ref.2 Ref.3 Ref.12 Ref.13 Ref.14May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation. Ref.1 Ref.2 Ref.3 Ref.12 Ref.13 Ref.14
Subunit structure: Binds to DNA as a homomultimer. Dimerization is induced by binding to calcium. Component of heteromultimeric potassium channels. Interacts with KCND2 and KCND3
By similarity. Interacts with the C-terminus of PSEN1 and PSEN2 and with PSEN2 CTF subunit. Associates with KCN1. Ref.11 Ref.18
Subcellular location: Cytoplasm. Cell membrane; Lipid-anchor
By similarity. Endoplasmic reticulum. Golgi apparatus. Nucleus. Note: Also membrane-bound, associated with the plasma membrane
By similarity. In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. Ref.11 Ref.17
Tissue specificity: Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease. Ref.16
Post-translational modification: Palmitoylated. Palmitoylation enhances association with the plasma membrane
By similarity.Proteolytically cleaved by caspase-3. Ref.11Phosphorylation at Ser-63 inhibits cleavage by CASP3.
Sequence similarities: Belongs to the recoverin family.Contains 4 EF-hand domains.
Research Articles on KCNIP3
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Product Notes
The KCNIP3 kcnip3 (Catalog #AAA647991) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CSEN (Calsenilin, Kv Channel-interacting Protein 3, A-type Potassium Channel Modulatory Protein 3, DRE-antagonist Modulator, DREAM, KCNIP3, KChIP3, MGC18289) reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CSEN can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the KCNIP3 kcnip3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MQPAKEVTKA SDGSLLGDLG HTPLSKKEGI KWQRPRLSRQ ALMRCCLVKW ILSSTAPQGS DSSDSELELS TVRHQPEGLD QLQAQTKFTK KELQSLYRGF KNECPTGLVD EDTFKLIYAQ FFPQGDATTY AHFLFNAFDA DGNGAIHFED FVVGLSILLR GTVHEKLKWA FNLYDINKDG YITKEEMLAI MKSIYDMMGR HTYPILREDA PAEHVERFFE KMDRNQDGVV TIEEFLEACQ KDENIMSSMQ LFENVI. It is sometimes possible for the material contained within the vial of "CSEN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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