Rabbit anti-Human, Mouse CSEN Polyclonal Antibody | anti-KCNIP3 antibody

CSEN (Calsenilin, Kv Channel-interacting Protein 3, A-type Potassium Channel Modulatory Protein 3, DRE-antagonist Modulator, DREAM, KCNIP3, KChIP3, MGC18289)

Cat. Num. AAA648305

• Gene Names: KCNIP3; CSEN; DREAM; KCHIP3
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: CSEN; Polyclonal Antibody; CSEN (Calsenilin; Kv Channel-interacting Protein 3; A-type Potassium Channel Modulatory Protein 3; DRE-antagonist Modulator; DREAM; KCNIP3; KChIP3; MGC18289); Anti -CSEN (Calsenilin; anti-KCNIP3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human KCNIP3. Species Crossreactivity: mouse.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MQPAKEVTKASDGSLLGDLGHTPLSKKEGIKWQRPRLSRQALMRCCLVKWILSSTAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQKDENIMSSMQLFENVI

• Applicable Applications for anti-KCNIP3 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human KCNIP3, aa1-256 (NP_038462.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(KCNIP3 rabbit polyclonal antibody. Western Blot analysis of KCNIP3 expression in mouse liver.)

Western Blot (WB)

(Western Blot analysis of KCNIP3 expression in transfected 293T cell line by KCNIP3 polyclonal antibody. Lane 1: KCNIP3 transfected lysate (29.2kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-KCNIP3 antibody

KChIP3 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease. Due to utilization of an alternate in-frame translation start codon, the gene for this protein encodes two isoforms with different sizes.

Product Categories/Family for anti-KCNIP3 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 78190495
• NCBI GeneID: 30818
• NCBI Accession #: NP_001030086.1
• NCBI GenBank Nucleotide #: NM_001034914.1
• UniProt Accession #: Q9Y2W7; Q3YAC3; Q3YAC4; Q53TJ5; Q96T40; Q9UJ84; Q9UJ85; H7BY46
• Molecular Weight: 29,231 Da
• NCBI Official Full Name: calsenilin isoform 2
• NCBI Official Synonym Full Names: Kv channel interacting protein 3, calsenilin
• NCBI Official Symbol: KCNIP3
• NCBI Official Synonym Symbols: CSEN; DREAM; KCHIP3
• NCBI Protein Information: calsenilin; DRE-antagonist modulator; kv channel-interacting protein 3; potassium channel interacting protein 3; A-type potassium channel modulatory protein 3; calsenilin, presenilin-binding protein, EF hand transcription factor
• UniProt Protein Name: Calsenilin
• Protein Family: Calsenilin
• UniProt Gene Name: KCNIP3
• UniProt Synonym Gene Names: CSEN; DREAM; KCHIP3; DREAM; KChIP3
• UniProt Entry Name: CSEN_HUMAN

NCBI Description

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception

By similarity. Ref.1 Ref.2 Ref.3 Ref.12 Ref.13 Ref.14Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and probably KCND3 trafficking to the cell surface. Ref.1 Ref.2 Ref.3 Ref.12 Ref.13 Ref.14May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation. Ref.1 Ref.2 Ref.3 Ref.12 Ref.13 Ref.14

Subunit structure: Binds to DNA as a homomultimer. Dimerization is induced by binding to calcium. Component of heteromultimeric potassium channels. Interacts with KCND2 and KCND3

By similarity. Interacts with the C-terminus of PSEN1 and PSEN2 and with PSEN2 CTF subunit. Associates with KCN1. Ref.11 Ref.18

Subcellular location: Cytoplasm. Cell membrane; Lipid-anchor

By similarity. Endoplasmic reticulum. Golgi apparatus. Nucleus. Note: Also membrane-bound, associated with the plasma membrane

By similarity. In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. Ref.11 Ref.17

Tissue specificity: Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease. Ref.16

Post-translational modification: Palmitoylated. Palmitoylation enhances association with the plasma membrane

By similarity.Proteolytically cleaved by caspase-3. Ref.11Phosphorylation at Ser-63 inhibits cleavage by CASP3.

Sequence similarities: Belongs to the recoverin family.Contains 4 EF-hand domains.