Goat CDw198 Polyclonal Antibody | anti-CDw198 antibody

GOAT ANTI MOUSE CDw198

Cat. Num. AAA223758

• Gene Names: Ccr8; C-C; CCR-8; CKR-8; mCCR8; Cmkbr8; CC-CKR-8; C-C CKR-8
• Applications: ELISA, Immunohistochemistry, Western Blot
• Synonyms: CDw198; Polyclonal Antibody; GOAT ANTI MOUSE CDw198; anti-CDw198 antibody

• Host: Goat
• Clonality: Polyclonal
• Isotype: IgG
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 1.0mg/ml (varies by lot)
• Sequence Length: 353

• Applicable Applications for anti-CDw198 antibody: ELISA (EIA), Immunohistology Paraffin, Western Blot (WB)
• Application Notes: ELISA: This product is suitable for use in indirect ELISA applications. ; ELISA: Maximum Dilution: 1/100000; Immunohistology - Paraffin: Maximum Dilution: 1/400; Western Blotting: Maximum Dilution: 1/1000
• Perservative Stabilisers: 0.1% Sodium Azide (NaN3)
• Histology Positive Control Tissue: Spleen; Buffer Solution
• Antiserum Preparation: Antiserum to mouse CDw198 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
• Target Species: Mouse
• Preparation and Storage: Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Testing Data #1

(Staining of paraffin embedded mouse spleen with Goat anti mouse CDw198 (MBS223758))

Related Product Information for anti-CDw198 antibody

Goat anti mouse CDw198 polyclonal antibody specifically recognizes mouse CDw198, otherwise known as CCR8 (C-C chemokine receptor type 8), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, which acts a high-affinity receptor for the chemokine I-309 (CCL1), implicated in the regulation of monocyte chemotaxis and thymocyte apoptosis. CDw198 is constitutively expressed by monocytes, preferentially expressed on Th2 (type 2 helper T) cells, and acts as a co-receptor with CD4 for HIV1 infection.

NCBI and Uniprot Product Information

• NCBI GI #: 6671774
• NCBI GeneID: 12776
• NCBI Accession #: NP_031746.1
• NCBI GenBank Nucleotide #: NM_007720.2
• UniProt Accession #: P56484
• Molecular Weight: 40,045 Da
• NCBI Official Full Name: C-C chemokine receptor type 8
• NCBI Official Synonym Full Names: chemokine (C-C motif) receptor 8
• NCBI Official Symbol: Ccr8
• NCBI Official Synonym Symbols: C-C; CCR-8; CKR-8; mCCR8; Cmkbr8; CC-CKR-8; C-C CKR-8
• NCBI Protein Information: C-C chemokine receptor type 8; C-C motif chemokine receptor 8
• UniProt Protein Name: C-C chemokine receptor type 8
• UniProt Gene Name: Ccr8
• UniProt Synonym Gene Names: Cmkbr8; Ter1; C-C CKR-8; CC-CKR-8; CCR-8
• UniProt Entry Name: CCR8_MOUSE

Uniprot Description

CCR8: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding; signal transducer activity; C-C chemokine receptor activity; chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; immune response; chemotaxis; signal transduction