Goat anti-Mouse CD196 Polyclonal Antibody | anti-CD196 antibody

GOAT ANTI HUMAN CD196

Cat. Num. AAA223815

• Gene Names: Ccr6; CCR-6; KY411; Cmkbr6; CC-CKR-6
• Reactivity: Mouse
• Applications: ELISA, Immunohistochemistry, Western Blot
• Synonyms: CD196; Polyclonal Antibody; GOAT ANTI HUMAN CD196; anti-CD196 antibody

• Host: Goat
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Goat anti Human CD196 antibody recognizes human CD196, otherwise known as CCR6 (C-C chemokine receptor type 6), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, which acts as a specific receptor for the C-C chemokine LARC (Liver and activation-regulated chemokine)/MIP-3alpha, a selective chemoattractant which induces calcium flux in CD196-expressing lymphocytes. CD196 is preferentially expressed by B cells, memory T cells and immature dendritic cells and plays an important role in B lineage maturation and antigen-driven B cell differentiation. CD196 acts as a co-receptor for HIV1 infection, and is selectively expressed by mucosa-associated non-Hodgkin's lymphoma, making the interaction between CD196 and LARC a potential therapeutic target in these malignancies. Goat anti Human CD196 antibody cross-reacts with mouse CD196, where linear epitopes are accessible.
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 1.0mg/ml (varies by lot)
• Sequence Length: 367

• Applicable Applications for anti-CD196 antibody: ELISA (EIA), Immunohistology Paraffin, Western Blot (WB)
• Application Notes: ELISA: This product is suitable for use in indirect ELISA applications. ; ELISA: Maximum Dilution: 1/35000; Immunohistology - Paraffin: Maximum Dilution: 1/125; Western Blotting: Maximum Dilution: 1/250
• Perservative Stabilisers: 0.1% Sodium Azide (NaN3); 0.1% Bovine Serum Albumin
• Immunogen: Synthetic peptide YFVSVNTSYYSVDSEMLLCSLQEVRQFSR corresponding to amino acids 18-46 of human CD196.; Histology Positive Control Tissue
• Antiserum Preparation: Antiserum to human CD196 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
• Target Species: Human
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Testing Data #1

(Paraffin embedded human spleen stained with Goat anti Human CD196 (MBS223815))

Testing Data #2

(Paraffin embedded mouse spleen stained with Goat anti Human CD196 (MBS223815))

Related Product Information for anti-CD196 antibody

Goat anti Human CD196 antibody recognizes human CD196, otherwise known as CCR6 (C-C chemokine receptor type 6), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, which acts as a specific receptor for the C-C chemokine LARC (Liver and activation-regulated chemokine)/MIP-3alpha, a selective chemoattractant which induces calcium flux in CD196-expressing lymphocytes. CD196 is preferentially expressed by B cells, memory T cells and immature dendritic cells and plays an important role in B lineage maturation and antigen-driven B cell differentiation. CD196 acts as a co-receptor for HIV1 infection, and is selectively expressed by mucosa-associated non-Hodgkin's lymphoma, making the interaction between CD196 and LARC a potential therapeutic target in these malignancies. Goat anti Human CD196 antibody cross-reacts with mouse CD196, where linear epitopes are accessible.

NCBI and Uniprot Product Information

• NCBI GI #: 298493288
• NCBI GeneID: 12458
• NCBI Accession #: NP_001177262.1
• NCBI GenBank Nucleotide #: NM_001190333.1
• Molecular Weight: 42,103 Da
• NCBI Official Full Name: C-C chemokine receptor type 6 isoform A
• NCBI Official Synonym Full Names: chemokine (C-C motif) receptor 6
• NCBI Official Symbol: Ccr6
• NCBI Official Synonym Symbols: CCR-6; KY411; Cmkbr6; CC-CKR-6
• NCBI Protein Information: C-C chemokine receptor type 6
• UniProt Protein Name: C-C chemokine receptor type 6
• UniProt Gene Name: Ccr6
• UniProt Synonym Gene Names: Cmkbr6; C-C CKR-6; CC-CKR-6; CCR-6
• UniProt Entry Name: CCR6_MOUSE

Uniprot Description

CCR6: Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Motility/polarity/chemotaxis; Membrane protein, multi-pass

Cellular Component: cell surface; membrane; plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; protein binding; signal transducer activity; C-C chemokine receptor activity; chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; immune response; chemotaxis; signal transduction