Western Blot (WB)
(Western blot analysis of Caspase-12 with rat kidney tissue lysate.)
Rabbit Caspase 12 Polyclonal Antibody | anti-CASP-12 antibody
Caspase 12 Antibody
Applications
Western Blot
Purity
Affinity Chromatography
Synonyms
Caspase 12; Polyclonal Antibody; Caspase 12 Antibody; Rabbit Polyclonal Caspase 12 Antibody; Polyclonal Caspase 12 antibody; anti-Caspase 12 antibody; Caspase 12 antibody; Caspase -12; CASP12 antibody; Caspase -12 antibody; CASP12P1 antibody; anti-CASP-12 antibody
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Chromatography
Form/Format
Supplied in PBS buffer, pH 7.2, containing 30% Glycerol, 0.5% BSA, 0.01% Thimerosal
Concentration
200 ug/ml (varies by lot)
Sequence Length
421
Applicable Applications for anti-CASP-12 antibody
Western Blot (WB)
Application Notes
WB: 0.5-4 ug/ml
Immunogen
Caspase 12 antibody was raised in Rabbit using synthetic peptide corresponding to residues surrounding amino acid 310 of mouse caspase-12 as the immunogen.
Cross-Reactivity
Mouse, Rat
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Western Blot (WB)
(Western blot analysis of Caspase-12 with rat kidney tissue lysate.)
Western Blot (WB)
(Western blot analysis of Caspase-12 with rat kidney tissue lysate.)
Related Product Information for anti-CASP-12 antibody
Three distinct signaling pathways lead to programmed cell death. The death receptor and mitochondrion pathways are the mains two pathways, in which the key apoptotic proteases caspase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is located to the ER, but not to the cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium hemeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein. Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.
Product Categories/Family for anti-CASP-12 antibody
NCBI and Uniprot Product Information
Similar Products
Product Notes
The CASP-12 (Catalog #AAA5311249) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Caspase 12 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 0.5-4 ug/ml. Researchers should empirically determine the suitability of the CASP-12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Caspase 12, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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