Testing Data
Rabbit anti-Human beta-Site APP Cleaving Enzyme Polyclonal Antibody
Anti-beta-Site APP Cleaving Enzyme Antibody
Reactivity
Human
Applications
Western Blot, Immunoprecipitation, ELISA
Purity
Purified
Synonyms
beta-Site APP Cleaving Enzyme; Polyclonal Antibody; Anti-beta-Site APP Cleaving Enzyme Antibody; beta-site APP-Cleaving Enzyme; anti-beta-Site APP Cleaving Enzyme antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
This antibody is directed against human BACE protein. The product was purified from monospecific antiserum by DEAE ion exchange chromatography. The antibody is human and mouse reactive. Reactivity against homologues from other sources has not been determined.
Purity/Purification
Purified
Form/Format
Liquid; PBS, pH 7.4 with 0.05% sodium azide.
Concentration
1ug/ul (varies by lot)
Applicable Applications for anti-beta-Site APP Cleaving Enzyme antibody
Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA)
Application Notes
This antibody has been tested for use in western blotting and immunohistochemistry. Human brain tissue can be used as a positive control in western blotting, and a band at approximately 70 kDa is expected.
Immunogen
This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the carboxyl terminus of human BACE protein.
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.
For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Testing Data
Testing Data
Testing Data
Testing Data
Related Product Information for anti-beta-Site APP Cleaving Enzyme antibody
Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor (APP) at b-and g-sites by two proteases. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as the substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all sufferers of Alzheimer's disease. The long-sought b-secretase was recently identified by several groups independently and designated b-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP.
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Product Notes
The beta-Site APP Cleaving Enzyme (Catalog #AAA4158588) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-beta-Site APP Cleaving Enzyme Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's beta-Site APP Cleaving Enzyme can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA). This antibody has been tested for use in western blotting and immunohistochemistry. Human brain tissue can be used as a positive control in western blotting, and a band at approximately 70 kDa is expected. Researchers should empirically determine the suitability of the beta-Site APP Cleaving Enzyme for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "beta-Site APP Cleaving Enzyme, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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