Rabbit anti-Human, Mouse ADAM22 Polyclonal Antibody | anti-ADAM22 antibody

ADAM22 Antibody

Cat. Num. AAA9630977

• Gene Names: ADAM22; MDC2; EIEE61; ADAM 22
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: ADAM22; Polyclonal Antibody; ADAM22 Antibody; A disintegrin and metalloproteinase domain 22; ADA22_HUMAN; ADAM 22; ADAM metallopeptidase domain 22; adam22; and cysteine-rich protein 2; Disintegrin and metalloproteinase domain-containing protein 22; disintegrin-like; MDC 2; MDC2; Metalloproteinase disintegrin ADAM22 3; Metalloproteinase like disintegrin like and cysteine rich protein 2; Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like; MGC149832; anti-ADAM22 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: ADAM22 Antibody detects endogenous levels of ADAM22.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-ADAM22 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human ADAM22.
• Conjugation: Unconjugated
• Post Translational Modifications: The precursor is cleaved by a furin endopeptidase.
• Subunit Structure: Interacts with LGI1. Interacts with DLG4/PSD95. Also binds LGI4 (By similarity). Interacts with KCNA2 and DLG2 (By similarity). Interacts (via C-terminus) with YWHAB/14-3-3 beta and YWHAZ/14-3-3 zeta but not with YWHAE/14-3-3 epsilon or YWHAH/14-3-3 eta.
• Tissue Specificity: Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues.
• Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-ADAM22 antibody

Cell membrane; Single-pass type I membrane protein; Cell projection; Axon; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 62204768
• NCBI GeneID: 53616
• UniProt Accession #: Q9P0K1; O75075; O75076; Q9P0K2; Q9UIA1; Q9UKK2
• Molecular Weight: 100,269 Da
• NCBI Official Full Name: ADAM22 protein
• NCBI Official Synonym Full Names: ADAM metallopeptidase domain 22
• NCBI Official Symbol: ADAM22
• NCBI Official Synonym Symbols: MDC2; EIEE61; ADAM 22
• NCBI Protein Information: disintegrin and metalloproteinase domain-containing protein 22
• UniProt Protein Name: Disintegrin and metalloproteinase domain-containing protein 22
• Protein Family: Disintegrin and metalloproteinase domain-containing protein
• UniProt Gene Name: ADAM22
• UniProt Synonym Gene Names: MDC2; ADAM 22

NCBI Description

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]

Uniprot Description

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.