Rabbit MMP11 Monoclonal Antibody | anti-MMP11 antibody

MMP11 Antibody

Cat. Num. AAA9435825

• Gene Names: MMP11; ST3; SL-3; STMY3
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry
• Purity: ProA affinity purified
• Synonyms: MMP11; Monoclonal Antibody; MMP11 Antibody; Matrix Metalloproteinase 11 antibody; Matrix metalloproteinase-11 antibody; MMP-11 antibody; Mmp11 antibody; MMP11_HUMAN antibody; SL 3 antibody; SL-3 antibody; SL3 antibody; ST3 antibody; STMY3 antibody; Stromelysin 3 antibody; Stromelysin III antibody; Stromelysin-3 antibody; anti-MMP11 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Clone Number: SN74-08
• Purity/Purification: ProA affinity purified
• Form/Format: 1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Applicable Applications for anti-MMP11 antibody: Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC)
• Application Notes: WB: 1:1000; IHC: 1:100-1:500; ICC: 1:500-1:1000
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant protein
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C.

Western Blot (WB)

(Western blot analysis of MMP11 on mouse spleen lysates using anti-MMP11 antibody at 1/1, 000 dilution.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-MMP11 antibody. Counter stained with hematoxylin.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-MMP11 antibody. Counter stained with hematoxylin.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti-MMP11 antibody. Counter stained with hematoxylin.)

Immunocytochemistry (ICC)

(ICC staining MMP11 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.)

Immunocytochemistry (ICC)

(ICC staining MMP11 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.)

Immunocytochemistry (ICC)

(ICC staining MMP11 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.)

Related Product Information for anti-MMP11 antibody

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including Collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also called stromelysin-1, -2 and -3) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.

Product Categories/Family for anti-MMP11 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 58331148
• NCBI GeneID: 4320
• NCBI Accession #: NP_005931.2
• NCBI GenBank Nucleotide #: NM_005940.3
• UniProt Accession #: P24347; Q5FX24; Q6PEZ6; Q9UC26
• Molecular Weight: 54,590 Da
• NCBI Official Full Name: stromelysin-3 preproprotein
• NCBI Official Synonym Full Names: matrix metallopeptidase 11 (stromelysin 3)
• NCBI Official Symbol: MMP11
• NCBI Official Synonym Symbols: ST3; SL-3; STMY3
• NCBI Protein Information: stromelysin-3; MMP-11; stromelysin III
• UniProt Protein Name: Stromelysin-3
• Protein Family: Stromelysin
• UniProt Gene Name: MMP11
• UniProt Synonym Gene Names: STMY3; SL-3; ST3; MMP-11
• UniProt Entry Name: MMP11_HUMAN

NCBI Description

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]

Uniprot Description

MMP11: May play an important role in the progression of epithelial malignancies. Belongs to the peptidase M10A family.

Protein type: Extracellular matrix; EC 3.4.24.-; Secreted, signal peptide; Protease; Secreted

Chromosomal Location of Human Ortholog: 22q11.23

Cellular Component: proteinaceous extracellular matrix; Golgi lumen; extracellular region

Molecular Function: zinc ion binding; metalloendopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; collagen fibril organization; multicellular organismal development; proteolysis; negative regulation of fat cell differentiation