NALP1 Blocking Peptide | NLRP1 blocking peptide

NALP1 Peptide

Cat. Num. AAA152933

• Gene Names: NLRP1; NAC; CARD7; CIDED; NALP1; SLEV1; DEFCAP; PP1044; VAMAS1; CLR17.1; DEFCAP-L/S
• Applications: Blocking (BL)
• Synonyms: NALP1; NALP1 Peptide; NAC; CARD7; CIDED; SLEV1; DEFCAP; PP1044; VAMAS1; CLR17.1; DEFCAP-L/S; KIAA0926; NACHT; LRR and PYD domains-containing protein 1; Caspase recruitment domain-containing protein 7; NLR family; pyrin domain containing 1; NLRP1 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 1429

• Applicable Applications for NLRP1 blocking peptide: Blocking (BL)
• Application Notes: NALP1 peptide is used for blocking the activity of NALP1 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 13 amino acids near the carboxy terminus of human NALP1.
• Preparation and Storage: Store NALP1 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 11096303
• NCBI GeneID: 22861
• UniProt Accession #: Q9C000; Q9BZZ8; Q9BZZ9; Q9H5Z7; Q9H5Z8; Q9HAV8; Q9UFT4; Q9Y2E0; E9PE50; I6L9D9
• Molecular Weight: 46,068 Da
• NCBI Official Full Name: NALP1
• NCBI Official Synonym Full Names: NLR family, pyrin domain containing 1
• NCBI Official Symbol: NLRP1
• NCBI Official Synonym Symbols: NAC; CARD7; CIDED; NALP1; SLEV1; DEFCAP; PP1044; VAMAS1; CLR17.1; DEFCAP-L/S
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 1; caspase recruitment domain protein 7; NACHT, LRR and PYD containing protein 1; NACHT, leucine rich repeat and PYD containing 1; caspase recruitment domain-containing protein 7; nucleotide-binding domain and caspase recruitment domain; death effector filament-forming Ced-4-like apoptosis protein; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 1
• Protein Family: NACHT, LRR and PYD domains-containing protein
• UniProt Gene Name: NLRP1
• UniProt Synonym Gene Names: CARD7; DEFCAP; KIAA0926; NAC; NALP1
• UniProt Entry Name: NALP1_HUMAN

NCBI Description

This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

NALP1: Able to form cytoplasmic structures termed death effector filaments. Enhances APAF1 and cytochrome c-dependent activation of pro-caspase-9 and consecutive apoptosis. Stimulates apoptosis through activation of caspase-3. Involved in activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of IL1B and IL18. Binds ATP. Interacts strongly with caspase-2, weakly with caspase-9 and with APAF1 in a cytochrome c-inducible way, leading to the formation of an apoptosome. This interaction may be ATP-dependent. Part of the NALP1 inflammasome complex which is involved in activation of caspase-1 and caspase-5, leading to processing of IL1B and IL18. The complex is activated by bacterial muramyl dipeptide which triggers ATP-binding and oligomerization of NALP1. Widely expressed. Isoform 1 and isoform 2 are expressed in peripheral blood leukocytes and chronic myelogenous leukemia cell line K-562, followed by thymus, spleen and heart. Also detected in brain, lung, placenta, small intestine, colon, kidney, liver, muscle, testis and epithelial cells. Absent from hematopoietic progenitor cells but expressed upon differentiation of cells into granulocytes and, to a lesser extent, monocytes. In peripheral blood cells, highest levels are found in T-lymphocytes, granulocytes and monocytes. Expression is significantly increased in bone marrow blast cells of some acute leukemia patients but not in solid tumors. Belongs to the NLRP family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: intracellular; cytosol; nucleus

Molecular Function: protein domain specific binding; protein binding; enzyme binding; caspase activator activity; ATP binding

Biological Process: caspase activation; neuron apoptosis; apoptosis; response to muramyl dipeptide; regulation of inflammatory response; defense response to bacterium; innate immune response; positive regulation of interleukin-1 beta secretion

Disease: Vitiligo-associated Multiple Autoimmune Disease Susceptibility 1; Corneal Intraepithelial Dyskeratosis And Ectodermal Dysplasia