Rabbit anti-Human NLRP1 Polyclonal Antibody | anti-NLRP1 antibody

NLRP1 Antibody

Cat. Num. AAA9416201

• Gene Names: NLRP1; NAC; CARD7; CIDED; NALP1; SLEV1; DEFCAP; PP1044; VAMAS1; CLR17.1; DEFCAP-L/S
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen Affinity Purification
• Synonyms: NLRP1; Polyclonal Antibody; NLRP1 Antibody; NAC; CARD7; CIDED; NALP1; SLEV1; DEFCAP; PP1044; VAMAS1; CLR17.1; DEFCAP-L/S; anti-NLRP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total NLRP1 protein.
• Purity/Purification: Antigen Affinity Purification
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 0.9 mg/ml (varies by lot)
• Sequence Length: 1375

• Applicable Applications for anti-NLRP1 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:20-1:100
• Immunogen: Synthetic peptide of human NLRP1
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/20.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using at dilution 1/20.)

Related Product Information for anti-NLRP1 antibody

This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells.Multiple alternatively spliced transcript variants encoding distinct isoformshave been found for this gene, but the biological validity of some variants has not been determined.

Product Categories/Family for anti-NLRP1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 74271814
• NCBI GeneID: 22861
• NCBI Accession #: NP_001028225.1
• NCBI GenBank Nucleotide #: NM_001033053.2
• UniProt Accession #: Q9C000; Q9BZZ8; Q9BZZ9; Q9H5Z7; Q9H5Z8; Q9HAV8; Q9UFT4; Q9Y2E0; E9PE50; I6L9D9
• Molecular Weight: 46,068 Da
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 1 isoform 5
• NCBI Official Synonym Full Names: NLR family, pyrin domain containing 1
• NCBI Official Symbol: NLRP1
• NCBI Official Synonym Symbols: NAC; CARD7; CIDED; NALP1; SLEV1; DEFCAP; PP1044; VAMAS1; CLR17.1; DEFCAP-L/S
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 1
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 1
• Protein Family: NACHT, LRR and PYD domains-containing protein
• UniProt Gene Name: NLRP1
• UniProt Entry Name: NLRP1_HUMAN

Uniprot Description

As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin (PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). Binds ATP (PubMed:11113115, PubMed:15212762).