Rat nuclear receptor co-repressor 1 ELISA Kit | NCOR1 elisa kit
Rat Nuclear receptor corepressor 1, NCOR1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
expressed in skeletal muscle [RGD, Feb 2006]
Uniprot Description
N-CoR1: is a protein that regulates the activity of some transcription factors, including nuclear receptors, by promoting histone deacetylation and chromatin condensation, thereby altering the accessibility of various genes to the transcriptional machinery. Is known to play a role genetic programming including that for myogenesis. Is a component of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid and the retinoic acid receptors in the absence of ligand. Interacts with the catalytic domain of HDAC9. Increased expression correlates with the loss of vitamin D responsiveness in aggressive androgen-independent prostate cancer cells. Its gene tends to be overexpressed in multiple-myeloma cell lines.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Cellular Component: transcription factor complex; transcriptional repressor complex; Sin3 complex; membrane; perinuclear region of cytoplasm; spindle microtubule; histone deacetylase complex; nuclear chromatin; cytoplasm; nucleus
Molecular Function: protein domain specific binding; peroxisome proliferator activated receptor binding; retinoic acid receptor binding; histone deacetylase binding; retinoid X receptor binding; protein binding; histone deacetylase regulator activity; DNA binding; sequence-specific DNA binding; estrogen receptor binding; thyroid hormone receptor binding; chromatin binding; transcription corepressor activity; transcription factor activity; nuclear hormone receptor binding
Biological Process: lactation; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; negative regulation of JNK cascade; regulation of histone deacetylation; skeletal muscle development; transcription, DNA-dependent; regulation of multicellular organism growth; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; spindle assembly; thalamus development; regulation of transcription from RNA polymerase II promoter; cholesterol homeostasis; positive regulation of histone deacetylation; regulation of catalytic activity; positive regulation of cell proliferation; cerebellum development; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; negative regulation of phosphoinositide 3-kinase cascade
Research Articles on NCOR1
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Product Notes
The Rat NCOR1 ncor1 (Catalog #AAA9326714) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326714 ELISA Kit recognizes Rat NCOR1. It is sometimes possible for the material contained within the vial of "nuclear receptor co-repressor 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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