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Western Blot (WB) (Western blot analysis on MDA-MB-435 cell lysate using NCoR1 Antibody.)

anti-Human, Mouse NCoR1 Antibody | anti-NCoR1 antibody

NCoR1 Antibody

Gene Names
NCOR1; N-CoR; TRAC1; N-CoR1; hN-CoR; PPP1R109
Reactivity
Human, Mouse
Applications
Western Blot, Immunohistochemistry
Purity
Affinity-chromatography
Synonyms
NCoR1; NCoR1 Antibody; hCIT529I10; hN-CoR; KIAA1047; MGC104216; N-CoR; N-CoR1; NCOR1; nuclear receptor co-repressor 1; Nuclear receptor corepressor 1; thyroid hormone-and retinoic acid receptor-associated corepressor 1; TRAC1; anti-NCoR1 antibody
Ordering
For Research Use Only!
Reactivity
Human, Mouse
Specificity
NCoR1 antibody detects endogenous levels of total NCoR1
Purity/Purification
Affinity-chromatography
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Sequence Length
914
Applicable Applications for anti-NCoR1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: 1:500~1:3000
IHC: 1:50~1:200
Immunogen
A synthesized peptide derived from human NCoR1
Preparation and Storage
Store at-20 degree C for 1 year

Western Blot (WB)

(Western blot analysis on MDA-MB-435 cell lysate using NCoR1 Antibody.)

Western Blot (WB) (Western blot analysis on MDA-MB-435 cell lysate using NCoR1 Antibody.)
Related Product Information for anti-NCoR1 antibody
N-CoR1 is a protein that regulates the activity of some transcription factors, including nuclear receptors, by promoting histone deacetylation and chromatin condensation, thereby altering the accessibility of various genes to the transcriptional machinery. Is known to play a role genetic programming including that for myogenesis. Is a component of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid and the retinoic acid receptors in the absence of ligand. Interacts with the catalytic domain of HDAC9.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
270kDa
NCBI Official Full Name
nuclear receptor corepressor 1 isoform 2
NCBI Official Synonym Full Names
nuclear receptor corepressor 1
NCBI Official Symbol
NCOR1
NCBI Official Synonym Symbols
N-CoR; TRAC1; N-CoR1; hN-CoR; PPP1R109
NCBI Protein Information
nuclear receptor corepressor 1
UniProt Protein Name
Nuclear receptor corepressor 1
UniProt Gene Name
NCOR1
UniProt Synonym Gene Names
KIAA1047; N-CoR; N-CoR1

NCBI Description

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

Uniprot Description

Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.

Research Articles on NCoR1

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Product Notes

The NCoR1 ncor1 (Catalog #AAA8510764) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The NCoR1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's NCoR1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500~1:3000 IHC: 1:50~1:200. Researchers should empirically determine the suitability of the NCoR1 ncor1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NCoR1, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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