AXL recombinant protein

Recombinant Human AXL protein, C-His Tag

Cat. Num. AAA1562996

• Gene Names: AXL; UFO; JTK11
• Purity: >90% as determined by SDS-PAGE
• Synonyms: AXL; Recombinant Human AXL protein; C-His Tag; Tyrosine-protein kinase receptor UFO; AXL oncogene; UFO; ARK Protein; JTK11 Protein; Tyro7 Protein; UFO Protein; AXL recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Tag: C-His Tag
• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human AXL (Met1-Pro449) was fused with the C-His Tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder or frozen liquid. They are shipped out with dry ice or blue ice unless customers require otherwise.

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Product Categories/Family for AXL recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 21536468
• NCBI GeneID: 558
• NCBI Accession #: NP_001690.2
• NCBI GenBank Nucleotide #: NM_001699.4
• UniProt Accession #: P30530; Q8N5L2; Q9UD27
• Molecular Weight: 99kDa
• NCBI Official Full Name: tyrosine-protein kinase receptor UFO isoform 2
• NCBI Official Synonym Full Names: AXL receptor tyrosine kinase
• NCBI Official Symbol: AXL
• NCBI Official Synonym Symbols: UFO; JTK11
• NCBI Protein Information: tyrosine-protein kinase receptor UFO; AXL oncogene; oncogene AXL; AXL transforming sequence/gene
• UniProt Protein Name: Tyrosine-protein kinase receptor UFO
• Protein Family: Tyrosine-protein kinase receptor
• UniProt Gene Name: AXL
• UniProt Synonym Gene Names: UFO
• UniProt Entry Name: UFO_HUMAN

NCBI Description

The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

AXL: a receptor tyrosine kinase that may function as a signal transducer between specific cell types of mesodermal origin. Interacts with SKP1. Overexpression in tissue culture causes oncogenic transformation. Overexpressed in several cancers including thyroid, ovarian, gastric, ER+ breast cancer and acute myeloid leukemia, where it is associated with poor prognosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Oncoprotein; Protein kinase, TK; TK group; Axl family

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: extracellular space; cell surface; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; phosphatidylserine binding; protein heterodimerization activity; protein-tyrosine kinase activity; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding; myosin heavy chain binding

Biological Process: forebrain cell migration; negative regulation of lymphocyte activation; platelet activation; organ regeneration; peptidyl-tyrosine phosphorylation; cell maturation; neuron migration; vagina development; negative regulation of tumor necrosis factor production; signal transduction; phagocytosis; positive regulation of natural killer cell differentiation; erythrocyte homeostasis; positive regulation of protein kinase B signaling cascade; ovulation cycle; natural killer cell differentiation; negative regulation of interferon-gamma production; protein kinase B signaling cascade; cellular response to extracellular stimulus; innate immune response; blood vessel remodeling; spermatogenesis; negative regulation of neuron apoptosis; positive regulation of cytokine and chemokine mediated signaling pathway; inflammatory response; vascular endothelial growth factor receptor signaling pathway; apoptotic cell clearance; secretion by cell