Mouse STAT1 Monoclonal Antibody | anti-STAT1 antibody

Mouse monoclonal STAT1 antibody

Cat. Num. AAA5307406

• Gene Names: Stat1; AA408197; 2010005J02Rik
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: STAT1; Monoclonal Antibody; Mouse monoclonal STAT1 antibody; STAT1 antibody; anti-STAT1 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 4H9
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 500 ug-1 mg/ml (varies by lot)
• Sequence Length: 749

• Applicable Applications for anti-STAT1 antibody: Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IF: 1:100; IHC: 1:50; WB: 1:2000
• Immunogen: STAT1 antibody was raised in mouse using a protein expressed in 293T cell transfected with human STAT1 expression vector as the immunogen.
• Cross-Reactivity: Human, Dog, Monkey
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Immunofluorescence (IF)

(Immunofluorescent staining of COS7 cells transiently transfected with recombinant STAT1 protein using STAT1 antibody)

Product Categories/Family for anti-STAT1 antibody

DNA & RNA

NCBI and Uniprot Product Information

• NCBI GI #: 458710
• NCBI GeneID: 20846
• Molecular Weight: 87,197 Da
• NCBI Official Full Name: Stat1
• NCBI Official Synonym Full Names: signal transducer and activator of transcription 1
• NCBI Official Symbol: Stat1
• NCBI Official Synonym Symbols: AA408197; 2010005J02Rik
• NCBI Protein Information: signal transducer and activator of transcription 1
• UniProt Protein Name: Signal transducer and activator of transcription 1
• Protein Family: Signal transducer and activator of transcription
• UniProt Gene Name: Stat1

Uniprot Description

STAT1: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 1 C1.1|1 26.81 cM

Cellular Component: axon; cell-cell adherens junction; cytoplasm; dendrite; nuclear chromatin; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm

Molecular Function: CCR5 chemokine receptor binding; DNA binding; double-stranded DNA binding; enzyme binding; nuclear hormone receptor binding; protein homodimerization activity; protein phosphatase 2A binding; sequence-specific DNA binding; transcription factor activity; tumor necrosis factor receptor binding

Biological Process: blood circulation; caspase activation; cellular response to insulin stimulus; cytokine and chemokine mediated signaling pathway; JAK-STAT cascade; lipopolysaccharide-mediated signaling pathway; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of viral protein levels in host cell; positive regulation of cell proliferation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to bacterium; response to cAMP; response to cytokine stimulus; response to drug; response to exogenous dsRNA; response to lipopolysaccharide; response to mechanical stimulus; response to nutrient; response to peptide hormone stimulus; transcription, DNA-dependent; tumor necrosis factor-mediated signaling pathway